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American Journal of Clinical Nutrition, Vol 36, 926-930, Copyright © 1982 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Quantitation of urinary niacin metabolites by reversed-phase liquid chromatography

EG Carter

The niacin metabolites N1-methyl-2-pyridone-5-carboxamide (2-PYR) and N1-methylnicotinamide (N-MN) have been quantified in human urine using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection after a simple anion-exchange clean-up procedure. The coefficients of variation (%) of the method for 2-PYR and N-MN were 6.3 and 6.8, respectively, and the limits of detection (mg/1 urine) were 0.05 for 2-PYR and 0.20 for N-MN. Results by this method compared favorably with those obtained by established techniques. It is a straight forward, rapid, and sensitive procedure for the assessment of niacin status.


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R. M. Menon, M. A. Gonzalez, M. H. Adams, D. S. Tolbert, J. H. Leu, and E. A. Cefali
Effect of the Rate of Niacin Administration on the Plasma and Urine Pharmacokinetics of Niacin and Its Metabolites
J. Clin. Pharmacol., June 1, 2007; 47(6): 681 - 688.
[Abstract] [Full Text] [PDF]


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