AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Snook, J. T.
Right arrow Articles by DeLany, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Snook, J. T.
Right arrow Articles by DeLany, J. P.
Agricola
Right arrow Articles by Snook, J. T.
Right arrow Articles by DeLany, J. P.

American Journal of Clinical Nutrition, Vol 37, 532-539, Copyright © 1983 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Supplementation frequency and ascorbic acid status in adult males

JT Snook, CP London and JP DeLany

This study was performed to determine if experimental subjects given ascorbic acid (AA) in a 240-mg dose every 4 days maintain blood levels of AA similar to levels of control subjects given 20 mg three times per day. All subjects ingested foods providing 6 to 7 mg AA/day but adequate in other nutrients. Mean serum AA for all subjects was 1.26 mg/dl initially indicating a habitual AA intake of over 100 mg/day. After 32 days on 66 mg AA/day, mean serum AA of control subjects remained below 0.7 mg/dl. After the first depletion period experimental subjects had significantly lower (p less than 0.05) serum AA than control subjects (0.74 versus 1.02 mg/dl). By the third depletion period experimental subjects adjusted to the less frequent dosage such that serum levels of AA were not lower. They were sometimes significantly higher (p less than 0.05) 1 day after the 240-mg dose. Experimental subjects had similar or higher mean white blood cell AA throughout the experiment. White blood cell AA was significantly (p less than 0.05) and negatively correlated with white blood cell count (r = -0.65) Results suggest that subjects adjust to receiving supplements of AA on a periodic basis at least under the conditions imposed in this study.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by The American Society for Nutrition