| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 38, 579-590, Copyright © 1983 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
RS Beach, ME Gershwin and LS Hurley
Recent work has shown that offspring of outbred mice deprived of adequate dietary zinc during the latter two-thirds of gestation exhibited a defective direct plaque-forming cell response to immunization with heterologous erythrocytes, as well as impaired ontogenesis of serum IgM. Moreover, such aberrant immunological measurements continued to be observed, although to a lesser degree, in F2 and F3 progeny. We now demonstrate that offspring of mice moderately deprived of zinc (5 ppm zinc diet) between days 7 and 20 of gestation also show an aberrant pattern of development of serum levels of IgG2a and IgA, despite complete nutritional rehabilitation beginning at birth. Only by 6 months of age were concentrations of these serum immunoglobulins similar to those in offspring of control dams. In contrast, levels of IgG1 and IgG2b were within normal ranges by 6 wk of age. Cross-fostering of zinc-deprived offspring to dams adequately nourished during pregnancy did little to ameliorate their aberrant pattern of serum immunoglobulin development. Defective maturation of serum IgG2a and IgA did not persist in F2 and F3 progeny. Nonetheless such 2nd and 3rd generation offspring continued to have higher than normal perinatal mortality. The alterations of immune ontogenesis in these mice could not be attributed to the persistence of abnormal plasma zinc levels, as these were within normal ranges. It would appear that zinc deficiency during gestation may alter the basic mechanism of development of immunological competence.
This article has been cited by other articles:
|
|
 |
|
  R. Raqib, M. B. Hossain, S. L. Kelleher, C. B. Stephensen, and B. Lonnerdal Zinc Supplementation of Pregnant Rats with Adequate Zinc Nutriture Suppresses Immune Functions in Their Offspring J. Nutr., April 1, 2007; 137(4): 1037 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ghattas, D. L Wallace, J. A Solon, S. M Henson, Y. Zhang, P. T Ngom, R. Aspinall, G. Morgan, G. E Griffin, A. M Prentice, et al. Long-term effects of perinatal nutrition on T lymphocyte kinetics in young Gambian men Am. J. Clinical Nutrition, February 1, 2007; 85(2): 480 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Langley-Evans, G. J. Phillips, and A. A. Jackson Fetal Exposure to Low Protein Maternal Diet Alters the Susceptibility of Young Adult Rats to Sulfur Dioxide-Induced Lung Injury J. Nutr., February 1, 1997; 127(2): 202 - 209. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
