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American Journal of Clinical Nutrition, Vol 38, 884-887, Copyright © 1983 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Depressed erythrocyte glutathione reductase activity in sickle cell disease

RN Varma, VN Mankad, DD Phelps, LD Jenkins and RM Suskind

In a group of 27 sickle cell disease patients ranging in age from 2 yr 3 months to 43 yr, 13 (48%) were found to have depressed erythrocyte glutathione reductase activity suggesting riboflavin deficiency. Glutathione reductase activity coefficients did not correlate with riboflavin intakes which were calculated from 3-day diet records returned by 16 patients. Other causes of riboflavin deficiency including decreased absorption, altered metabolism, or increased excretion of the vitamin must be considered. The potential effect of depressed erythrocyte glutathione reductase activity in the sickle cell disease process is discussed.


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Copyright © 1983 by The American Society for Nutrition