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American Journal of Clinical Nutrition, Vol 39, 223-226, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Lack of effect of vitamin E therapy on the anemia of patients receiving hemodialysis

V Sinsakul, JR Drake, JN Leavitt Jr, BR Harrison and CD Fitch

We conducted a prospective, randomized, double-blind therapeutic trial of vitamin E as an erythropoietic agent in a group of patients with chronic renal failure who were undergoing chronic hemodialysis. Sixteen patients received 400 IU of vitamin E (d-alpha-tocopheryl acetate) by mouth twice daily and 19 patients received a placebo twice daily for 20 wk. The serum vitamin E concentration increased from 1.3 to 2.6 mg/dl in the treated group and decreased from 1.3 to 1.1 in the placebo group. For the treated group the initial hematocrit was 24.8 +/- 3.0 (mean +/- SD) and the final hematocrit was 25.8 +/- 3.8. For the placebo group the initial hematocrit was 24.9 +/- 3.0 and the final hematocrit was 23.5 +/- 2.7. The treated group received a total of 40 blood transfusions, and the placebo group received a total of 35 blood transfusions. Thus, vitamin E had no effect on the anemia or transfusion requirements of patients undergoing chronic hemodialysis for chronic renal failure.


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 Nutr Clin PractHome page
R. Wolk
Micronutrition in Dialysis
Nutr Clin Pract, December 1, 1993; 8(6): 267 - 276.
[Abstract] [PDF]


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Copyright © 1984 by The American Society for Nutrition