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American Journal of Clinical Nutrition, Vol 39, 514-519, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Kinetics and metabolic effects of orally administered ornithine alpha- ketoglutarate in healthy subjects fed with a standardized regimen

L Cynober, M Vaubourdolle, A Dore and J Giboudeau

In accordance with previous results obtained with traumatized patients, ornithine alpha-ketoglutarate (OKG) was orally administered to 10 healthy subjects fed with a standardized regimen. Six similarly fed control subjects received only water. Plasma and 24-h urinary amino acids and alpha-ketoglutarate, plasma glucose, plasma insulin, and urine urea were all measured. After administration of ornithine alpha- ketoglutarate, the rapid decrease in blood ornithine to basal values, the absence of any increase in plasma alpha-ketoglutarate levels, and the minimal increase in ornithine, alpha-ketoglutarate, and urea urinary elimination, all indicated intense metabolism and utilization of the two compounds. These results suggest that the hyperornithinemia observed in 4-h fasting, traumatized patients receiving ornithine alpha- ketoglutarate reflects a metabolic perturbation in the utilization of this amino acid after trauma, rather than a hypothetical slow utilization. On the other hand, ornithine alpha-ketoglutarate induced an increase in insulin levels causing hypoglycemia and probably a decrease in plasma levels of several amino acids.


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L. Cynober
Pharmacokinetics of Arginine and Related Amino Acids
J. Nutr., June 1, 2007; 137(6): 1646S - 1649S.
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Copyright © 1984 by The American Society for Nutrition