American Journal of Clinical Nutrition, Vol 39, 612-618, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of dietary sucrose on the SHR/N-corpulent rat: a new model for insulin-independent diabetes

OE Michaelis 4th, KC Ellwood, JM Judge, NW Schoene and CT Hansen

A new congenic strain of genetically obese rat, SHR/N-corpulent (cp), was studied. Young male corpulent (cp/cp) and lean (cp/+ or +/+) rats approximately 5 wk of age were fed a diet containing 54% carbohydrate as either sucrose or cooked cornstarch for 9 wk. A phenotype effect was observed with body weight, fasting levels of serum insulin, triglyceride and total cholesterol, levels of serum insulin and glucose after an oral glucose load, and level of urine glucose (corpulent greater than lean), and with systolic blood pressure (corpulent less than lean). Only lean rats were hypertensive. Corpulent rats were hyperinsulinemic, hyperlipidemic, exhibited glycosuria, and were hyperglycemic after an oral glucose load. Lean rats were hyperinsulinemic, but normoglycemic. A diet effect (sucrose greater than starch) was observed with body weight, level of serum glucose after an oral glucose load, and urine volume in both corpulent and lean rats, and with levels of serum insulin and total urine glucose in corpulent rats. Corpulent rats fed sucrose had 20 to 40% higher levels of serum glucose and insulin after an oral glucose load, and twice the amount of total urine glucose, than did corpulent rats fed starch. The data demonstrate that corpulent rats have metabolic characteristics associated with insulin-independent diabetes in humans and that sucrose is more diabetogenic than starch. Manifestation of hyperglycemia in this model may be the result of superimposing obesity on an insulin- resistant genetic background.

This article has been cited by other articles:

				S. J. Bhathena, A. A. Ali, C. Haudenschild, P. Latham, T. Ranich, A. I. Mohamed, C. T. Hansen, and M. T. Velasquez Dietary Flaxseed Meal is More Protective Than Soy Protein Concentrate Against Hypertriglyceridemia and Steatosis of the Liver in an Animal Model of Obesity J. Am. Coll. Nutr., April 1, 2003; 22(2): 157 - 164. [Abstract] [Full Text] [PDF]

				A. Soria, M. E. D'Alessandro, and Y. B. Lombardo Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes J Appl Physiol, November 1, 2001; 91(5): 2109 - 2116. [Abstract] [Full Text] [PDF]

				M. T. Velasquez, J. S. Striffler, A. A. Abraham, O. E. Michaelis IV, E. Scalbert, and N. Thibault Perindopril Ameliorates Glomerular and Renal Tubulointerstitial Injury in the SHR/N-Corpulent Rat Hypertension, November 1, 1997; 30(5): 1232 - 1237. [Abstract] [Full Text]

				T. Yamakawa, S.-i. Tanaka, K. Tamura, F. Isoda, K. Ukawa, Y. Yamakura, Y. Takanashi, Y. Kiuchi, S. Umemura, M. Ishii, et al. Wistar Fatty Rat Is Obese and Spontaneously Hypertensive Hypertension, January 1, 1995; 25(1): 146 - 150. [Abstract] [Full Text]