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American Journal of Clinical Nutrition, Vol 40, 208-218, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Dynamics of selenite metabolism in young men: studies with the stable isotope tracer method

M Janghorbani, LJ Kasper and VR Young

Dynamics of selenite metabolism in young adult North American men were studied using an amino acid diet and the stable isotope tracer methodology during a short-term selenium replete-restriction phase. During the initial 10 days subjects consumed the diet providing a total daily selenium intake of 107.7 +/- 0.1 micrograms mostly as selenite. This was followed by selenium restriction at 11.4 +/- 0.1 micrograms/day (as impurities from diet components) for the next 34 days. Kinetic studies with the stable isotope tracer 74SeO32- were carried out on days 4 and 39 of the study. Kinetics of excretion of the tracer in feces and urine were followed from which body retention curves were constructed. The retention curves were resolved into two exponential decay components with half-lives of 2.4 +/- 0.3 and 162 +/- 9 days (mean +/- 1 SEM), respectively. Retention data and urine isotope enrichment curves were combined to determine dynamics of changes in the apparent body pool size for selenite (10.4 mg at t----infinity) as well as rates of turnover for this parameter.


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 JPEN J Parenter Enteral NutrHome page
R. F. Martin, M. Janghorbani, and V. R. Young
Kinetics of a Single Administration of 74Se-Selenite by Oral and Intravenous Routes in Adult Humans
JPEN J Parenter Enteral Nutr, July 1, 1988; 12(4): 351 - 355.
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Copyright © 1984 by The American Society for Nutrition