American Journal of Clinical Nutrition, Vol 40, 536-541, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effects of iron, tin, and copper on zinc absorption in humans

LS Valberg, PR Flanagan and MJ Chamberlain

Zinc absorption as measured by body retention of [65Zn]zinc chloride or a turkey test meal extrinsically labeled with 65Zn was determined in human subjects by whole body counting after 7 days. Average 65Zn absorption from zinc chloride in persons with a high iron-absorbing capacity was similar to persons with a low capacity to absorb iron. Inorganic iron, 920 mumol (51 mg), or HB iron, 480 mumol (26 mg), inhibited 65Zn absorption from 92 mumol (6 mg) of zinc chloride. When 610 mumol of iron (34 mg) was added to a turkey test meal containing 61 mumol of zinc (4 mg), 65Zn absorption was not inhibited. Tin, 306 mumol (36 mg), given with zinc chloride or turkey test meals (61 mumol, 4 mg, of Zn) significantly reduced 65Zn absorption. Copper, 79 mumol (5 mg), had no significant effect on the 65Zn absorption from 7.9 mumol (0.5 mg) of zinc chloride. In summary, the capacity to absorb iron did not influence 65Zn absorption, but both inorganic iron and heme-iron inhibited 65Zn absorption from zinc chloride. Inorganic iron had no effect, however, on 65Zn absorption from the turkey test meal. Tin in a large dose also inhibited 65Zn absorption from both zinc chloride and the turkey test meal.

This article has been cited by other articles:

				P. Etcheverry, G. E Carstens, E. Brown, K. M Hawthorne, Z. Chen, and I. J Griffin Production of stable-isotope-labeled bovine heme and its use to measure heme-iron absorption in children Am. J. Clinical Nutrition, February 1, 2007; 85(2): 452 - 459. [Abstract] [Full Text] [PDF]

				K. Alarcon, P. W Kolsteren, A. M Prada, A. M Chian, R. E Velarde, I. L Pecho, and T. F Hoeree Effects of separate delivery of zinc or zinc and vitamin A on hemoglobin response, growth, and diarrhea in young Peruvian children receiving iron therapy for anemia Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1276 - 1282. [Abstract] [Full Text] [PDF]

				T. Lind, B. Lonnerdal, H. Stenlund, I. L Gamayanti, D. Ismail, R. Seswandhana, and L.-A. Persson A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development Am. J. Clinical Nutrition, September 1, 2004; 80(3): 729 - 736. [Abstract] [Full Text] [PDF]

				F. J Troost, R.-J. M Brummer, J. R Dainty, J. A Hoogewerff, V. J Bull, and W. H. Saris Iron supplements inhibit zinc but not copper absorption in vivo in ileostomy subjects Am. J. Clinical Nutrition, November 1, 2003; 78(5): 1018 - 1023. [Abstract] [Full Text] [PDF]

				T. Lind, B. Lonnerdal, H. Stenlund, D. Ismail, R. Seswandhana, E.-C. Ekstrom, and L.-A. Persson A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: interactions between iron and zinc Am. J. Clinical Nutrition, April 1, 2003; 77(4): 883 - 890. [Abstract] [Full Text] [PDF]

				K. R. Zinn, T. R. Chaudhuri, J. M. Mountz, G. J. van den Berg, D. T. Gordon, and G. L. Johanning 59Fe Is Retained from an Elemental 59Fe Powder Supplement without Effects on 65Zinc, 47Calcium and 67Copper in Young Pigs J. Nutr., January 1, 1999; 129(1): 181 - 187. [Abstract] [Full Text] [PDF]

				B. Sandström Toxicity Considerations When Revising the Nordic Nutrition Recommendations J. Nutr., February 1, 1998; 128(2): 372 - 372. [Abstract] [Full Text]

				P. B. Acosta, S. Stepnick-Gropper, N. Clarke-Sheehan., E. Wenz, M. Cheng, K. Anderson, and R. Koch Trace Element Status of PKU Children Ingesting an Elemental Diet JPEN J Parenter Enteral Nutr, May 1, 1987; 11(3): 287 - 292. [Abstract] [PDF]