AJCN EB Program 2010 Early Registration
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, M. U.
Right arrow Articles by van Itallie, T. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, M. U.
Right arrow Articles by van Itallie, T. B.
Agricola
Right arrow Articles by Yang, M. U.
Right arrow Articles by van Itallie, T. B.

American Journal of Clinical Nutrition, Vol 40, 611-622, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Variability in body protein loss during protracted, severe caloric restriction: role of triiodothyronine and other possible determinants

MU Yang and TB van Itallie

Six morbidly obese subjects were maintained in a metabolic ward for 64 days on liquid diets providing 600 to 800 kcal/day. Three received protein at a level of 1.5 g/kg desirable weight per day. The other three were given an identical diet in which half the protein was replaced by carbohydrate. Because there were no significant differences in either mean protein or mean fat losses between the two groups, the data on all six subjects were combined. Over the 64 days, the mean weight loss (+/- SEM) of the subjects per 1000 kcal deficit was 174.3 +/- 25.5 g. The composition of this weight loss was 36.0% water, 58.9% fat, and 5.1% protein. Although the rate of fat loss was relatively constant throughout the study, wide interindividual variations in cumulative protein (nitrogen) deficit were observed. Total nitrogen losses per subject ranged from 90.5 to 278.7 g. Cumulative nitrogen loss during the first 16 days tended to correlate negatively with initial mean fat cell size and positively with initial lean body mass. Most notable was the strong negative correlation between the size of the decrease in serum triiodothyronine over the 64-day study and the magnitude of the concurrent cumulative N deficit. During severe caloric restriction, one's ability to decrease circulating serum triiodothyronine levels may be critical to achievement of an adaptational decrease in body protein loss.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
A. Bosy-Westphal, E. Kossel, K. Goele, W. Later, B. Hitze, U. Settler, M. Heller, C.-C. Gluer, S. B Heymsfield, and M. J Muller
Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure
Am. J. Clinical Nutrition, October 1, 2009; 90(4): 993 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
A. Raman, R. J. Colman, Y. Cheng, J. W. Kemnitz, S. T. Baum, R. Weindruch, and D. A. Schoeller
Reference Body Composition in Adult Rhesus Monkeys: Glucoregulatory and Anthropometric Indices
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2005; 60(12): 1518 - 1524.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
R. T. Ferraro and J. Albu
Nutrition Support of the Critically Ill Obese Patient
Nutr Clin Pract, August 1, 1989; 4(4): 125 - 126.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 by The American Society for Nutrition