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American Journal of Clinical Nutrition, Vol 40, 763-770, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of different linoleic acid intakes on prostaglandin biosynthesis and kidney function in man

O Adam and G Wolfram

Prostaglandin (PG) biosynthesis and kidney function was investigated in 24 adults (23 to 32 yr) during isocaloric formula diet periods, for 2 wk each, providing a linoleic acid supply of 0, 3, 3.5, 4, 6, 8, 13, 17, 18, or 20% of total energy intake. Total protein intake (15 energy %) was constant, as well as 5 g NaCl, 3 g KCl, and 0.6 g cholesterol per 2200 kcal formula diet. The amount of PG metabolites, PG-E, sodium, and creatinine in 24-h urine increased with augmented linoleic acid intake. Comparing a linoleic acid intake of 0 and 20 energy %, an increase of sodium (8%) and creatinine (16%) in 24-h urine was found on the 5th day of high linoleic acid supply. Coincidently a stimulated PG biosynthesis could be measured. Potassium, water, and PG-F excretion showed no relation to linoleic acid intake. It is concluded that linoleic acid in the diet stimulates PG-E biosynthesis in man, leading to effects in systems which control renal function, and may have clinical relevance for the sodium and potassium balance in man.


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