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American Journal of Clinical Nutrition, Vol 40, 1131-1136, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Decreased hepatic vitamin A after drug administration in men and in rats

MA Leo, N Lowe and CS Lieber

Eleven patients with moderate drug-induced liver changes were found to have extremely low hepatic vitamin A levels (less than 10% of normal). Their serum vitamin A, retinol-binding protein, and transthyretin were only slightly affected. In rats, two representative drugs (phenobarbital and methylcholanthrene) produced a significant depression of hepatic vitamin A, whereas plasma vitamin A levels remained normal. The livers of drug-treated animals showed no abnormalities except for the expected proliferation of the smooth endoplasmic reticulum and induction of microsomal enzymes and cytochrome P-450 (phenobarbital) and P-448 (methylcholanthrene). These findings suggest that the decrease in hepatic vitamin A may be secondary, at least in part, to enhanced microsomal metabolism.


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M. A Leo and C. S Lieber
Alcohol, vitamin A, and {beta}-carotene: adverse interactions, including hepatotoxicity and carcinogenicity
Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1071 - 1085.
[Abstract] [Full Text] [PDF]


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Copyright © 1984 by The American Society for Nutrition