AJCN EB Program 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leek, J. C.
Right arrow Articles by Hendrickx, A. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leek, J. C.
Right arrow Articles by Hendrickx, A. G.
Agricola
Right arrow Articles by Leek, J. C.
Right arrow Articles by Hendrickx, A. G.

American Journal of Clinical Nutrition, Vol 40, 1203-1212, Copyright © 1984 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal effects

JC Leek, JB Vogler, ME Gershwin, MS Golub, LS Hurley and AG Hendrickx

Skeletal maturation was evaluated in newborn and infant rhesus monkeys that had been subjected to a marginally zinc-deficient diet (4 ppm zinc) from conception through 12 months of postnatal life. Serial radiographic assessment of skeletal development was performed and compared to both ad libitum and pair-fed controls. Radiographs were obtained at birth and at 1, 3, 9, and 12 months of age. In each age group a maturation indicator was selected to identify individuals with abnormal skeletal maturation defined on the basis of presence of epiphyseal ossification centers. Animals were compared only within a given sex group. Additionally, to evaluate endochondral bone mineralization, the appearance of the zone of provisional calcification on the metaphyseal side of the growth plate and the width of the growth plate were assessed. A marginal level of zinc deprivation during gestation and during the 1st yr of life was found to be associated with significantly delayed skeletal maturation and defective mineralization. This abnormality of bone mineralization has many features similar to human rachitic syndromes and suggests that zinc plays an important role in endochondral bone formation.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
R. G. Erben, K. Lausmann, P. Roschger, C. Schuler, M. Skalicky, K. Klaushofer, and W. Windisch
Long-Term Marginal Zinc Supply Is Not Detrimental to the Skeleton of Aged Female Rats
J. Nutr., April 1, 2009; 139(4): 703 - 709.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. K. Chandyo, T. A. Strand, M. Mathisen, M. Ulak, R. K. Adhikari, B. J. Bolann, and H. Sommerfelt
Zinc Deficiency Is Common among Healthy Women of Reproductive Age in Bhaktapur, Nepal
J. Nutr., March 1, 2009; 139(3): 594 - 597.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. Merialdi, L. E Caulfield, N. Zavaleta, A. Figueroa, K. A Costigan, F. Dominici, and J. A Dipietro
Randomized controlled trial of prenatal zinc supplementation and fetal bone growth
Am. J. Clinical Nutrition, May 1, 2004; 79(5): 826 - 830.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. F. Olivieri and G. M. Brittenham
Iron-Chelating Therapy and the Treatment of Thalassemia
Blood, February 1, 1997; 89(3): 739 - 761.
[Full Text] [PDF]

Home page
 The Journal of the Royal Society for the Promotion of HealthHome page
K. Simmer and R.P.H. Thompson
Zinc And The Fetus
Perspectives in Public Health, October 1, 1986; 106(5): 166 - 168.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 by The American Society for Nutrition