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American Journal of Clinical Nutrition, Vol 42, 252-262, Copyright © 1985 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Studies of marginal zinc deprivation in rhesus monkeys: VI. Influence on the immunohematology of infants in the first year

DC Haynes, ME Gershwin, MS Golub, AT Cheung, LS Hurley and AG Hendrickx

Rhesus monkey infants fed a marginally zinc-deficient diet (4 ppm) from conception through 12 mo of postnatal life were monitored for changes in hematological, biochemical, and immunological parameters. These zinc- deprived (ZD) infants were compared to control infants whose mothers were fed a zinc-replete (100 ppm) diet either ad libitum (AL) or pair- fed (PF) throughout gestation and lactation. Blast transformation of peripheral blood lymphocytes to phytohemagglutinin (PHA-P), concanavalin A (Con A), and pokeweed mitogen (PWM), was dramatically depressed in the zinc-deficient (ZD) group. Similarly, ZD infants had reduced polymorphonuclear leukocyte function as measured by chemotaxis to endotoxin-activated plasma and phagocytosis of Candida albicans. Levels of serum IgM were significantly altered in zinc-deficient infants compared to controls. Serum concentrations of IgG and IgA were similar in zinc-deficient and control infants. ZD infants also manifested a hypochromic microcytic anemia at one month of age, reduced activity of the zinc metalloenzyme alkaline phosphatase, and lower activity of SGPT.


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M J. Heinig, K. H Brown, B. Lonnerdal, and K. G Dewey
Zinc supplementation does not affect growth, morbidity, or motor development of US term breastfed infants at 4-10 mo of age.
Am. J. Clinical Nutrition, September 1, 2006; 84(3): 594 - 601.
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Copyright © 1985 by The American Society for Nutrition