AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 42, 1044-1049, Copyright © 1985 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Satiety signals from the gastrointestinal tract

HS Koopmans

Experiments in rats with crossed intestines have shown that signals arising in a 30 cm segment of upper small intestine do not affect the short-term control of food intake. The combined stimulus of neural and hormonal signals arising in the crossed intestinal segment and of absorbed food do not inhibit intake during a subsequent meal. The relevant satiety signals must arise in either the stomach and upper duodenum or in the lower small intestine. A transplanted stomach study has shown that a hormone released from the stomach is responsible for the termination of a single meal. Other studies show that neural or hormonal signals coming from the lower small intestine are important in the regulation of total daily food intake and in the long-term regulation of body weight.





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Copyright © 1985 by The American Society for Nutrition