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American Journal of Clinical Nutrition, Vol 42, 1044-1049, Copyright © 1985 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
HS Koopmans
Experiments in rats with crossed intestines have shown that signals arising in a 30 cm segment of upper small intestine do not affect the short-term control of food intake. The combined stimulus of neural and hormonal signals arising in the crossed intestinal segment and of absorbed food do not inhibit intake during a subsequent meal. The relevant satiety signals must arise in either the stomach and upper duodenum or in the lower small intestine. A transplanted stomach study has shown that a hormone released from the stomach is responsible for the termination of a single meal. Other studies show that neural or hormonal signals coming from the lower small intestine are important in the regulation of total daily food intake and in the long-term regulation of body weight.
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