American Journal of Clinical Nutrition, Vol 43, 136-150, Copyright © 1986 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Influence of long-term diet modification on platelet function and composition in Moselle farmers

S Renaud, F Godsey, E Dumont, C Thevenon, E Ortchanian and JL Martin

Platelet function and composition, lipemia, and dietary habits were evaluated yearly in 98 male farmers from Moselle (East of France) before and after decreasing, in half of them, dietary saturated fats from 16.2% to 9.9% of calories (P/S from 0.32 to 0.97). One year after these dietary changes, cholesterol and triglycerides decreased by approximately 10%, platelet aggregation to thrombin by 81%, and their clotting activity by 30%. However, ADP aggregation was enhanced by 54%. At 2 yr the P/S was decreased to 0.7 and diet also modified in controls, with 18:2 being increased mostly in one group (P/S = 0.81) and 18:3 in another (P/S = 0.59). In both groups, the main platelet function tests were significantly depressed 1 yr later. Considering the whole study, the intake of saturated fat was mostly correlated (group and individual) with platelet aggregation to thrombin, platelet clotting activity, and 20:3 (n-9) in plasma and platelet lipids.

This article has been cited by other articles:

				H. Iso, S. Sato, A. Kitamura, Y. Naito, T. Shimamoto, and Y. Komachi Fat and Protein Intakes and Risk of Intraparenchymal Hemorrhage among Middle-aged Japanese Am. J. Epidemiol., January 1, 2003; 157(1): 32 - 39. [Abstract] [Full Text] [PDF]

				A. P. Simopoulos The Mediterranean Diets: What Is So Special about the Diet of Greece? The Scientific Evidence J. Nutr., November 1, 2001; 131(11): 3065S - 3073. [Abstract] [Full Text] [PDF]

				H. Iso, M. J. Stampfer, J. E. Manson, K. Rexrode, F. B. Hu, C. H. Hennekens, G. A. Colditz, F. E. Speizer, and W. C. Willett Prospective Study of Fat and Protein Intake and Risk of Intraparenchymal Hemorrhage in Women Circulation, February 13, 2001; 103(6): 856 - 863. [Abstract] [Full Text] [PDF]

				A. P Simopoulos Essential fatty acids in health and chronic disease Am. J. Clinical Nutrition, September 1, 1999; 70(3): 560S - 569. [Abstract] [Full Text] [PDF]

				S. M. Innis and R. A. Dyer Dietary Canola Oil Alters Hematological Indices and Blood Lipids in Neonatal Piglets Fed Formula J. Nutr., July 1, 1999; 129(7): 1261 - 1268. [Abstract] [Full Text]

				E. Guallar, A. Aro, F. J. Jimenez, J. M. Martin-Moreno, I. Salminen, P. van't Veer, A. F. M. Kardinaal, J. Gomez-Aracena, B. C. Martin, L. Kohlmeier, et al. Omega-3 Fatty Acids in Adipose Tissue and Risk of Myocardial Infarction : The EURAMIC Study Arterioscler. Thromb. Vasc. Biol., April 1, 1999; 19(4): 1111 - 1118. [Abstract] [Full Text] [PDF]

				T.A.B. Sanders Diet and Coronary Heart Disease The Journal of the Royal Society for the Promotion of Health, October 1, 1987; 107(5): 163 - 165.