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American Journal of Clinical Nutrition, Vol 43, 234-238, Copyright © 1986 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Dietary carnitine intake related to skeletal muscle and plasma carnitine concentrations in adult men and women

DL Lennon, ER Shrago, M Madden, FJ Nagle and P Hanson

The purpose of this investigation was to determine if there was any relationship between dietary carnitine intake and the concentrations of carnitine in skeletal muscle and blood plasma in healthy adult men and women. Subjects (14 men, 14 women, fasted 8 h) reported to the Biodynamics Laboratory where they completed a 24-h diet recall questionnaire. Resting muscle biopsy (vastus lateralis) and blood plasma samples were taken and assayed for free, short-chain, and long- chain acyl carnitine concentrations. Dietary carnitine intake was estimated from data on concentrations in food. There was no significant relationship between either protein or carnitine intake with skeletal muscle carnitine concentrations. There was a significant relationship between both dietary carnitine (r = 0.50) and protein (r = 0.48) intake with blood plasma total acid soluble carnitine concentrations (p less than 0.01) in all subjects.


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E. P. Brass
Pivalate-Generating Prodrugs and Carnitine Homeostasis in Man
Pharmacol. Rev., December 1, 2002; 54(4): 589 - 598.
[Abstract] [Full Text] [PDF]




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