AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koo, S. I.
Right arrow Articles by Henderson, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koo, S. I.
Right arrow Articles by Henderson, D. A.
Agricola
Right arrow Articles by Koo, S. I.
Right arrow Articles by Henderson, D. A.

American Journal of Clinical Nutrition, Vol 43, 429-437, Copyright © 1986 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C- cholesterol in marginally zinc-deficient rats

SI Koo, K Algilani, JE Norvell and DA Henderson

Previously, chylomicrons from marginally zinc-deficient rats were shown to be abnormally large, with markedly reduced levels of apoproteins C and E. In the present study, effects of such changes on the plasma clearance and hepatic uptake of chylomicron cholesterol were investigated in rats fed 3 ppm of zinc (ZD), as compared with those fed 30 ppm of zinc (CT). The rate of plasma clearance was determined by plasma 14C-radioactivity at different intervals after intravenous injection of lymph chylomicrons labeled in vivo with 14C-cholesterol. The 14C-clearance curves were nonlinear, consisting of an initial rapid phase followed by a slow phase of clearance. The initial 14C-clearance was significantly (p less than 0.05) delayed whether the labeled chylomicrons from ZD donors were injected into ZD or CT recipients. The hepatic 14C-recovery in extracted lipids was also significantly lower in ZD rats. The present data provide first evidence that a marginal level of zinc deficiency produces a significant delay in the plasma clearance and hepatic uptake of chylomicron cholesterol. This may be attributable in part to the molecular alterations of chylomicrons induced by zinc deficiency.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
S. K. Reaves, J. Y. J. Wu, Y. Wu, J. C. Fanzo, Y. R. Wang, P. P. Lei, and K. Y. Lei
Regulation of Intestinal Apolipoprotein B mRNA Editing Levels by a Zinc-Deficient Diet and cDNA Cloning of Editing Protein in Hamsters
J. Nutr., September 1, 2000; 130(9): 2166 - 2173.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
S. K. Reaves, J. C. Fanzo, J. Y. J. Wu, Y. R. Wang, Y. W. Wu, L. Zhu, and K. Y. Lei
Plasma Apolipoprotein B-48, Hepatic Apolipoprotein B mRNA Editing and Apolipoprotein B mRNA Editing Catalytic Subunit-1 mRNA Levels Are Altered in Zinc-Deficient Rats
J. Nutr., October 1, 1999; 129(10): 1855 - 1861.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by The American Society for Nutrition