American Journal of Clinical Nutrition, Vol 43, 752-757, Copyright © 1986 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Fish oil attenuates the cholesterol induced rise in lipoprotein cholesterol

PJ Nestel

Fish oils rich in n-3 fatty acids lower plasma triglyceride profoundly but the effect on plasma cholesterol is not clear. This study tested the capacity of MaxEPA oil to modify the rise in lipoprotein cholesterol during cholesterol-rich diets. Six subjects were tested with three diets: 1) habitual (P/S 0.47, cholesterol 710 mg/d); 2) fish oil (40 g/d MaxEPA, P/S 1.62, cholesterol 190 mg/d); 3) fish oil + egg yolk (P/S 1.62, cholesterol 940 mg/d). Changing from habitual to fish oil significantly lowered cholesterol and triglyceride levels in plasma, VLDL, LDL, and HDL and in plasma apo-A1 and apo-B. However the addition of 750 mg/d cholesterol to the fish oil failed to raise lipoprotein cholesterol or apoprotein levels significantly, although plasma cholesterol rose slightly; n-3 fatty acids are therefore capable of lowering lipoprotein cholesterol even when the intake of cholesterol is high.

This article has been cited by other articles:

				P. Benatti, G. Peluso, R. Nicolai, and M. Calvani Polyunsaturated Fatty Acids: Biochemical, Nutritional and Epigenetic Properties J. Am. Coll. Nutr., August 1, 2004; 23(4): 281 - 302. [Abstract] [Full Text] [PDF]

				F. J. Sanchez-Muniz, M. C. Garcia-Linares, M. T. Garcia-Arias, S. Bastida, and J. Viejo Fat and Protein from Olive Oil-Fried Sardines Interact to Normalize Serum Lipoproteins and Reduce Liver Lipids in Hypercholesterolemic Rats J. Nutr., July 1, 2003; 133(7): 2302 - 2308. [Abstract] [Full Text] [PDF]

				A.P. Simopoulos Evolutionary aspects of diet, essential fatty acids and cardiovascular disease Eur. Heart J. Suppl., June 1, 2001; 3(suppl_D): D8 - D21. [Abstract] [PDF]

				R. M Weggemans, P. L Zock, and M. B Katan Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis Am. J. Clinical Nutrition, May 1, 2001; 73(5): 885 - 891. [Abstract] [Full Text] [PDF]

				A. M. Minihane, S. Khan, E. C. Leigh-Firbank, P. Talmud, J. W. Wright, M. C. Murphy, B. A. Griffin, and C. M. Williams ApoE Polymorphism and Fish Oil Supplementation in Subjects With an Atherogenic Lipoprotein Phenotype Arterioscler. Thromb. Vasc. Biol., August 1, 2000; 20(8): 1990 - 1997. [Abstract] [Full Text] [PDF]

				A. P Simopoulos Essential fatty acids in health and chronic disease Am. J. Clinical Nutrition, September 1, 1999; 70(3): 560S - 569. [Abstract] [Full Text] [PDF]

				T. A. B. Sanders, F. R. Oakley, G. J. Miller, K. A. Mitropoulos, D. Crook, and M. F. Oliver Influence of n-6 versus n-3 Polyunsaturated Fatty Acids in Diets Low in Saturated Fatty Acids on Plasma Lipoproteins and Hemostatic Factors Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3449 - 3460. [Abstract] [Full Text]