| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 44, 173-180, Copyright © 1986 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
SW Corbett, JS Stern and RE Keesey
Effects of a diet high in fat on body weight, adiposity, and energy expenditure were investigated. Male rats were fed 8% (control) or 50% fat (by weight) for 6 mo. The high-fat group increased body weight (+26%), adipocyte size (+61%), and adipocyte number (+48%). However, food intake and resting oxygen consumption, although higher in absolute amount, were normal in that both were commensurate with the greater body mass the rats maintained. When body weight and adipocyte size were reduced by caloric restriction, the high-fat group displayed the same adaptive adjustments in resting oxygen consumption as controls. We conclude that rats fed high-fat diets for prolonged periods 1) have energy intakes and expenditures appropriate for the greater tissue mass and adipocyte number they maintain, and 2) show adaptive reductions in energy expenditure when food is restricted, which provide further evidence that the regulated level of body weight can be altered by such diets.
This article has been cited by other articles:
|
|
 |
|
  M. Schroeder, L. Shbiro, O. Zagoory-Sharon, T. H. Moran, and A. Weller Toward an animal model of childhood-onset obesity: follow-up of OLETF rats during pregnancy and lactation Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R224 - R232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Patterson, A. A. Dunn-Meynell, and B. E. Levin Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R290 - R301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Levin Why some of us get fat and what we can do about it J. Physiol., September 1, 2007; 583(2): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, K. Guo, R. E. LeBlanc, D. Loh, G. J. Schwartz, and Y.-H. Yu Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms Diabetes, June 1, 2007; 56(6): 1647 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Taylor and L. Poston Developmental programming of obesity in mammals Exp Physiol, March 1, 2007; 92(2): 287 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. MacLean, J. A. Higgins, M. R. Jackman, G. C. Johnson, B. K. Fleming-Elder, H. R. Wyatt, E. L. Melanson, and J. O. Hill Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1577 - R1588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Levin The drive to regain is mainly in the brain Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1297 - R1300. [Full Text] [PDF]
|
|
|
|
|
|
P. S. MacLean, J. A. Higgins, G. C. Johnson, B. K. Fleming-Elder, W. T. Donahoo, E. L. Melanson, and J. O. Hill Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1306 - R1315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. MacLean, J. A. Higgins, G. C. Johnson, B. K. Fleming-Elder, J. C. Peters, and J. O. Hill Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R288 - R297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Levin and A. A. Dunn-Meynell Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R771 - R778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Ricci and B. E. Levin Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R610 - R618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Tagliaferro and A. M. Ronan Physiological levels and action of dehydroepiandrosterone in Yucatan miniature swine Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R1 - R9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Levin and A. A. Dunn-Meynell Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R231 - R237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Levin Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R382 - R387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Levin and R. E. Keesey Defense of differfing body weight set points in diet-induced obese and resistant rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R412 - R419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Keesey and M. D. Hirvonen Body Weight Set-Points: Determination and Adjustment J. Nutr., September 1, 1997; 127(9): 1875 - 1875. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
