American Journal of Clinical Nutrition, Vol 44, 353-361, Copyright © 1986 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Sterol excretion and cholesterol absorption in diabetics and nondiabetics with and without hyperlipidemia [published erratum appears in Am J Clin Nutr 1987 Mar;45(3):640]

ER Briones, DL Steiger, PJ Palumbo, WM O'Fallon, AL Langworthy, BR Zimmerman and BA Kottke

Fecal neutral and acidic sterols and cholesterol absorption were measured in 12 normal control subjects, 40 diabetic subjects with and without hyperlipidemia, and 27 subjects with hyperlipidemia but without diabetes mellitus. All subjects were on a low-cholesterol diet (less than 300 mg cholesterol/day). Fecal excretion of neutral and acidic sterols was increased in patients with hypertriglyceridemia and was more marked in diabetic patients with hypertriglyceridemia. Cholesterol absorption was decreased in diabetic patients with hypertriglyceridemia. Otherwise, there were no significant differences in sterol excretion or cholesterol absorption in diabetic and nondiabetic subjects compared with control groups with similar lipid levels. The best predictors of fecal neutral- and acidic-sterol excretion and of estimated cholesterol synthesis were very low [corrected]-density lipoprotein triglycerides and high-density lipoprotein cholesterol. Correction of hyperlipidemia may be beneficial in decreasing cholesterol synthesis and, thereby, in decreasing the risk of atherogenesis.

This article has been cited by other articles:

				M. Hao, W. S. Head, S. C. Gunawardana, A. H. Hasty, and D. W. Piston Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic {beta}-Cell Dysfunction Diabetes, September 1, 2007; 56(9): 2328 - 2338. [Abstract] [Full Text] [PDF]

				V. W. Lau, M. Journoud, and P. J. Jones Plant sterols are efficacious in lowering plasma LDL and non-HDL cholesterol in hypercholesterolemic type 2 diabetic and nondiabetic persons Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1351 - 1358. [Abstract] [Full Text] [PDF]

				H. Gylling, J. A. Tuominen, V. A. Koivisto, and T. A. Miettinen Cholesterol Metabolism in Type 1 Diabetes Diabetes, September 1, 2004; 53(9): 2217 - 2222. [Abstract] [Full Text] [PDF]

				T. A. Miettinen, H. Gylling, J. Tuominen, P. Simonen, and V. Koivisto Low Synthesis and High Absorption of Cholesterol Characterize Type 1 Diabetes Diabetes Care, January 1, 2004; 27(1): 53 - 58. [Abstract] [Full Text] [PDF]

				L. Berglund and D. Hyson Cholesterol Absorption and the Metabolic Syndrome: A New Look at an Old Area Arterioscler. Thromb. Vasc. Biol., August 1, 2003; 23(8): 1314 - 1316. [Full Text] [PDF]

				P. P. Simonen, H. K. Gylling, and T. A. Miettinen Diabetes Contributes to Cholesterol Metabolism Regardless of Obesity Diabetes Care, September 1, 2002; 25(9): 1511 - 1515. [Abstract] [Full Text] [PDF]

				S. Maggi, N. Minicuci, T. Harris, L. Motta, M. Baldereschi, A. Di Carlo, D. Inzitari, and G. Crepaldi High Plasma Insulin and Lipids Profile in Older Individuals: The Italian Longitudinal Study on Aging J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2001; 56(4): 236M - 242. [Abstract] [Full Text]

				P. Simonen, H. Gylling, A. N Howard, and T. A Miettinen Introducing a new component of the metabolic syndrome: low cholesterol absorption Am. J. Clinical Nutrition, July 1, 2000; 72(1): 82 - 88. [Abstract] [Full Text] [PDF]

				M. S. Bosner, L. G. Lange, W. F. Stenson, and R. E. Ostlund , Jr. Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry J. Lipid Res., February 1, 1999; 40(2): 302 - 308. [Abstract] [Full Text]