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American Journal of Clinical Nutrition, Vol 44, 384-389, Copyright © 1986 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Vitamin A status of preterm infants: the influence of feeding and vitamin supplements

CW Woodruff, CB Latham, EP James and JE Hewett

Consecutive weekly determinations of plasma retinol, alpha-tocopherol, retinol-binding protein, prealbumin, and zinc were performed on a group of 58 infants weighing less than 2000 g at birth in an intensive-care nursery. Data were classified by the feeding regimen of the preceding week: parenteral, premature formula, or own mother's milk. Mean plasma- retinol values were less than 20 mcg/dl, the lower limit of normal for adults, with the highest values in the formula-fed group. Retinol- binding protein and prealbumin values were lowest in the parenterally- fed group. Alpha-tocopherol concentrations were consistently maintained at levels higher than 500 mcg/dl only in infants fed their own mother's milk. Mean zinc concentrations above 70 mcg/dl, the lower limit of normal for adults, occurred only in parenterally fed infants. Doubling the recommended vitamin supplement in formula-fed infants did not produce a significant increase in plasma retinol or tocopherol.


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J. P. Shenai
Vitamin A Supplementation in Very Low Birth Weight Neonates: Rationale and Evidence
Pediatrics, December 1, 1999; 104(6): 1369 - 1374.
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