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American Journal of Clinical Nutrition, Vol 44, 899-906, Copyright © 1986 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Serum copper and ceruloplasmin levels and urinary copper excretion in thermal injury

MG Boosalis, JT McCall, LD Solem, DH Ahrenholz and CJ McClain

Conflicting reports regarding copper status in thermal injury patients have been published. We determined serial serum-copper and serum- ceruloplasmin levels and 24-h urinary excretion of copper in 23 patients with second- and third-degree thermal burns. Throughout hospitalization, mean serum-copper concentration was significantly depressed; lowest levels were found in patients with greater than 40% total body surface area burns. Serum ceruloplasmin was also depressed, an unexpected finding because this protein is a positive acute-phase reactant poststress. Mean urinary excretion of copper was elevated, reaching 2.5 times the upper limit of normal 2 wk postburn. Depressed serum-copper levels paralleled the serum-ceruloplasmin levels rather than the increased urinary-copper losses. Further studies are required to determine the mechanism(s) of this altered copper metabolism and whether physiological or biochemical evidence of copper deficiency accompanies the observed hypocupremia.




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Copyright © 1986 by The American Society for Nutrition