American Journal of Clinical Nutrition, Vol 45, 564-569, Copyright © 1987 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity

AG Dulloo and DS Miller

Chronic administration of aspirin to obese mice had no effect on energy balance and body composition. In contrast, ephedrine increased energy expenditure by 9% and reduced body weight and body fat by 18% and 50%, respectively: obesity, however, was reduced but not reversed. In the presence of both ephedrine and aspirin, increase in energy expenditure found during treatment with ephedrine alone was doubled, and the obese group lost greater than 75% of body fat: obesity was reversed. These studies indicate that although aspirin administered alone has no influence on energy balance it can markedly potentiate thermogenic properties of ephedrine, effects which led to a normalization of body composition of the obese to that of the lean. Such ephedrine-aspirin mixtures, often found in over-the-counter preparations for asthma and bronchial disorders, could be put to new use as aids for treatment of human obesity.

This article has been cited by other articles:

				S. Dehoney and M. Wellein Rhabdomyolysis associated with the nutritional supplement Hydroxycut Am. J. Health Syst. Pharm., January 15, 2009; 66(2): 142 - 148. [Abstract] [Full Text] [PDF]

				K. J Acheson, G. Gremaud, I. Meirim, F. Montigon, Y. Krebs, L. B Fay, L.-J. Gay, P. Schneiter, C. Schindler, and L. Tappy Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am. J. Clinical Nutrition, January 1, 2004; 79(1): 40 - 46. [Abstract] [Full Text] [PDF]