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American Journal of Clinical Nutrition, Vol 45, 1492-1502, Copyright © 1987 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Long-term marginal zinc deprivation in rhesus monkeys. I. Effects on adult female breeders before conception

DC Haynes, MS Golub, ME Gershwin, AT Cheung, LS Hurley and AG Hendrickx

To assess long-term effects of marginal zinc deprivation on pregnancy, adult non-pregnant female rhesus monkeys were fed diets containing 100 or 4 ppm zinc for 1 yr. then mated; effects on pregnancy and its outcome are under study. During this year, food intake was not depressed in zinc-deprived (ZD) monkeys, and there were relatively few effects on biochemical or hematological indices. By the end of the year, plasma zinc concentration was somewhat lower in ZD monkeys than in controls. Several immune variables, including serum IgM and IgG levels and polymorphonuclear leukocyte (PMN) function, were depressed in the ZD group, changes closely reflecting circannual fluctuations in plasma zinc levels in both diet groups. Endotoxin-activated plasma from ZD monkeys had less potential to promote chemotaxis than that from control monkeys, suggesting that defective PMN function may relate to a plasma effect. Marginal zinc deprivation may thus influence immune function before other variables are affected.


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 Hum Exp ToxicolHome page
A G Hendrickx, N Makori, and P Peterson
Nonhuman primates: their role in assessing developmental effects of immunomodulatory agents
Human and Experimental Toxicology, April 1, 2000; 19(4): 219 - 225.
[Abstract] [PDF]


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Copyright © 1987 by The American Society for Nutrition