American Journal of Clinical Nutrition, Vol 46, 1-4, Copyright © 1987 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Comparison of oral and intravenous administration of sodium bromide for extracellular water measurements

N Vaisman, PB Pencharz, G Koren and JK Johnson

Extracellular water (ECW) is a component of body composition and an indicator of nutritional status. Although bromide has been used to measure ECW, no data regarding serial measurements are available. We attempted to validate giving bromide orally and to determine whether serial measurements of ECW are possible. Seven healthy adult volunteers were studied. Each received 1 cc 3% NaBr solution per kg body weight once intravenously and 3 times orally over 6 wk. Bromide concentrations were determined by neutron activation. ECW did not differ significantly at 2, 3, or 4 h after drug administration although there was a small but significant difference between modes of administration (p = less than 0.05). With repeated oral doses the estimate of ECW was unchanged; thus, oral bromide can be used for serial determination of ECW.

This article has been cited by other articles:

				D. R. Mager, L. J. Wykes, E. A. Roberts, R. O. Ball, and P. B. Pencharz Branched-Chain Amino Acid Needs in Children with Mild-to-Moderate Chronic Cholestatic Liver Disease J. Nutr., January 1, 2006; 136(1): 133 - 139. [Abstract] [Full Text] [PDF]

				G. Sergi, L. Lupoli, S. Volpato, R. Bertani, A. Coin, E. Perissinotto, I. Calliari, E. M. Inelmen, L. Busetto, and G. Enzi Body Fluid Distribution in Elderly Subjects with Congestive Heart Failure Ann. Clin. Lab. Sci., October 1, 2004; 34(4): 416 - 422. [Abstract] [Full Text] [PDF]

				S. K. Das, S. B. Roberts, J. J. Kehayias, J. Wang, L. K. G. Hsu, S. A. Shikora, E. Saltzman, and M. A McCrory Body composition assessment in extreme obesity and after massive weight loss induced by gastric bypass surgery Am J Physiol Endocrinol Metab, June 1, 2003; 284(6): E1080 - E1088. [Abstract] [Full Text] [PDF]

				A. C Buchholz, C. F McGillivray, and P. B Pencharz Differences in resting metabolic rate between paraplegic and able-bodied subjects are explained by differences in body composition Am. J. Clinical Nutrition, February 1, 2003; 77(2): 371 - 378. [Abstract] [Full Text] [PDF]

				M. J. Hamadeh, A. Schiffrin, and L. J. Hoffer Sulfate production depicts fed-state adaptation to protein restriction in humans Am J Physiol Endocrinol Metab, August 1, 2001; 281(2): E341 - E348. [Abstract] [Full Text] [PDF]

				M. J. Hamadeh and L. J. Hoffer Use of sulfate production as a measure of short-term sulfur amino acid catabolism in humans Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E857 - E866. [Abstract] [Full Text] [PDF]

				I. E. STAMATELATOS and J. J. KEHAYIAS Estimation of Extracellular Water by Instrumental Neutron Activation Analysis of Bromine Ann. N.Y. Acad. Sci., May 1, 2000; 904(1): 152 - 153. [Full Text] [PDF]

				W. Watson;, Z. Wang, and S. B. Heymsfield Hydration of fat-free body mass: new physiological modeling approach Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E752 - E753. [Full Text]

				M. J. Hamadeh, L. Robitaille, D. Boismenu, P. Hongsprabhas, O. A. Mamer, and L. J. Hoffer Human Extracellular Water Volume Can Be Measured Using the Stable Isotope Na234SO4 J. Nutr., March 1, 1999; 129(3): 722 - 727. [Abstract] [Full Text]

				M Azcue, M Rashid, A Griffiths, and P B Pencharz Energy expenditure and body composition in children with Crohn's disease: effect of enteral nutrition and treatment with prednisolone Gut, August 1, 1997; 41(2): 203 - 208. [Abstract] [Full Text] [PDF]

				S. F. Siconolfi, R. J. Gretebeck, W. W. Wong, R. A. Pietrzyk, and S. S. Suire Assessing total body and extracellular water from bioelectrical response spectroscopy J Appl Physiol, February 1, 1997; 82(2): 704 - 710. [Abstract] [Full Text] [PDF]