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American Journal of Clinical Nutrition, Vol 46, 91-94, Copyright © 1987 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
FA Campos, H Flores and BA Underwood
The effect of an infective episode of chickenpox on the vitamin A status of preschool-aged children was evaluated by use of the relative dose response (RDR) test. Status was determined before and 30, 120, and 180 d after administration of a single oral high-dosage (200,000 IU) supplement of vitamin A. No differences in mean blood levels of retinol or percentage of children showing a positive RDR were apparent until after the infective episode that occurred approximately 90 d after dosing. At 180 d postsupplementation, 74% of children who had been infected tested positive by the RDR, indicative of an inadequate liver reserve of vitamin A, in contrast to only 10% who had not been infected. Paired RDR observations at 0 and 180 d postsupplementation confirmed that the infective episode caused an accelerated depletion of liver reserves of vitamin A.
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