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American Journal of Clinical Nutrition, Vol 46, 295-301, Copyright © 1987 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Folate conjugase activity in the plasma and tumors of breast-cancer patients

JE Baggott, DC Heimburger, CL Krumdieck and CE Butterworth Jr

The activity of folate conjugase (pteroylpolyglutamate hydrolase, EC 3.4.22.12) was measured in plasma from normal subjects and patients with breast cancer using pteroylglutamyl-gamma-glutamyl-gamma-(U14C) glutamate as the substrate. Conjugase assays also were performed on samples of breast-tumor tissue, normal breast, and fibroadenoma. When assayed at pH 4.5 and 7.4, mean plasma conjugase activity was significantly (p less than 0.05) elevated in a group of patients with anatomically proven metastatic disease (n = 21) when compared with control subjects (n = 12) and a group of patients (n = 13) with no clinical evidence of disease after mastectomies. Mean plasma conjugase activity assayed at pH 4.5 also was significantly higher in the metastatic disease group when compared with breast cancer patients before mastectomy (n = 9) and fibroadenoma patients before biopsy (n = 3). The specific activity of tissue conjugase assayed at pH 4.5 was significantly higher (p less than or equal to 0.05) in infiltrating ductal carcinoma than in normal adjacent breast tissue according to the Wilcoxon test for paired samples (n = 10).


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R. Yao, Z. Nimec, T. J. Ryan, and J. Galivan
Identification, Cloning, and Sequencing of a cDNA Coding for Rat [IMAGE]-Glutamyl Hydrolase
J. Biol. Chem., April 12, 1996; 271(15): 8525 - 8528.
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Copyright © 1987 by The American Society for Nutrition