AJCN Tufts Nutrition Symposium, Boston Sept 24-26
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stampfer, M. J.
Right arrow Articles by Deykin, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stampfer, M. J.
Right arrow Articles by Deykin, D.
Agricola
Right arrow Articles by Stampfer, M. J.
Right arrow Articles by Deykin, D.

American Journal of Clinical Nutrition, Vol 47, 700-706, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels

MJ Stampfer, JA Jakubowski, D Faigel, R Vaillancourt and D Deykin
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.

A randomized, placebo-controlled double-blind trial was conducted on 20 adults to assess the effect of vitamin E (800 IU/d 727 mg/d for 5 wk) on platelet function, arachidonic acid metabolism, and prostacyclin generation. Platelet aggregation was measured in response to collagen, arachidonic acid, and adenosine diphosphate. Thromboxane B2 was assayed in serum and in the supernatant plasma after platelet aggregation. Platelets were labeled with [3H]arachidonic acid to assess production and release of cyclooxygenase products (MDA, TXB2, and HHT), a lipoxygenase product (12-HETE), and arachidonic acid in response to stimulation by thrombin or collagen. Prostacyclin was measured in plasma and in blood collected from bleeding-time incisions by a sensitive HPLC-RIA procedure. Despite marked increases in plasma and erythrocyte vitamin E levels in the vitamin E group, there were no significant differences between the vitamin E and placebo groups in any of the variables measured.


This article has been cited by other articles:


Home page
 J. Am. Coll. Nutr.Home page
J. Arnaud, M. Bost, D. Vitoux, J. Labarere, P. Galan, H. Faure, S. Hercberg, J.-C. Bordet, A.-M. Roussel, and P. Chappuis
Effect of Low Dose Antioxidant Vitamin and Trace Element Supplementation on the Urinary Concentrations of Thromboxane and Prostacyclin Metabolites
J. Am. Coll. Nutr., October 1, 2007; 26(5): 405 - 411.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. Liu, A. Wallmon, C. Olsson-Mortlock, R. Wallin, and T. Saldeen
Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms
Am. J. Clinical Nutrition, March 1, 2003; 77(3): 700 - 706.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. Melhus, V. Herbert, S. N. Meydani, M. Meydani, L. S. Leka, and J. B. Blumberg
Vitamin E Supplementation and Immune Response in Elderly Patients
JAMA, February 18, 1998; 279(7): 505 - 506.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
I. Jialal, C. J. Fuller, and B. A. Huet
The Effect of {alpha}-Tocopherol Supplementation on LDL Oxidation : A Dose-Response Study
Arterioscler. Thromb. Vasc. Biol., February 1, 1995; 15(2): 190 - 198.
[Abstract] [Full Text]

Home page
 NEJMHome page
J. H. O'Keefe, C. J. Lavie, M. Steiner, L. H. Powell, H. R. Black, J. L. Sullivan, M. J. Stampfer, E. B. Rimm, W. C. Willett, and D. Steinberg
Vitamin E and the Risk of Coronary Disease
N. Engl. J. Med., November 4, 1993; 329(19): 1424 - 1426.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by The American Society for Nutrition