American Journal of Clinical Nutrition, Vol 47, 715-721, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Comparison of parenteral nutrition and enteral feeding with pectin in experimental colitis in the rat

RH Rolandelli, SH Saul, RG Settle, DO Jacobs, SO Trerotola and JL Rombeau
Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia 19104.

The effect of a pectin-supplemented enteral diet on experimental colitis was compared with parenteral nutrition and with a pectin-free enteral diet. Forty-five rats had feeding catheters placed into either the stomach (IG, n = 31) or the superior vena cava (IV, n = 14) and then received acetic acid (colitis) or saline (control) enemas. After the enema, all rats received the same diet, either IG or IV, for 6 d except for 15 rats (IGP, 9 colitis and 6 controls), which had 1% pectin added to the diet. At the end of the feeding period the IGP group had significantly less colonic inflammation and/or necrosis than either IV (p less than 0.03) or IG (p less than 0.04) groups. Nitrogen balance, serum albumin, total iron-binding capacity and body weight did not differ significantly among dietary regimens. Thus, the degree of bowel injury in experimental colitis was decreased when animals were fed a pectin-supplemented enteral diet and this effect was independent of nutritional status.

This article has been cited by other articles:

				C. Cherbut, C. Michel, and G. Lecannu The Prebiotic Characteristics of Fructooligosaccharides Are Necessary for Reduction of TNBS-Induced Colitis in Rats J. Nutr., January 1, 2003; 133(1): 21 - 27. [Abstract] [Full Text] [PDF]

				J.-I. Togawa, H. Nagase, K. Tanaka, M. Inamori, T. Umezawa, A. Nakajima, M. Naito, S. Sato, T. Saito, and H. Sekihara Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance Am J Physiol Gastrointest Liver Physiol, July 1, 2002; 283(1): G187 - G195. [Abstract] [Full Text] [PDF]

				C K Ameho, A A Adjei, E K Harrison, K Takeshita, T Morioka, Y Arakaki, E Ito, I Suzuki, A D Kulkarni, A Kawajiri, et al. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha  production in trinitrobenzene sulphonic acid induced colitis Gut, October 1, 1997; 41(4): 487 - 493. [Abstract] [Full Text] [PDF]

				S. Bengmark and B. Jeppsson Gastrointestinal Surface Protection and Mucosa Reconditioning JPEN J Parenter Enteral Nutr, September 1, 1995; 19(5): 410 - 415. [Abstract] [PDF]

				K. A. Kudsk Invited Review: Clinical Applications of Enteral Nutrition Nutr Clin Pract, October 1, 1994; 9(5): 165 - 171. [Abstract] [PDF]

				D. Friedel and G. M. Levine Effect of Short-Chain Fatty Acids on Colonic Function and Structure JPEN J Parenter Enteral Nutr, January 1, 1992; 16(1): 1 - 4. [Abstract] [PDF]

				J. C. Palacio and J. L. Rombeau Invited Review: Dietary Fiber: A Brief Review and Potential Application To Enteral Nutrition Nutr Clin Pract, June 1, 1990; 5(3): 99 - 106. [PDF]