American Journal of Clinical Nutrition, Vol 47, 1030-1035, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Metabolic differences between subjects whose blood pressure did or did not respond to oral calcium supplementation

RM Lyle, CL Melby and GC Hyner
Health Promotion Section, Purdue University, West Lafayette, IN 47907.

In a randomized, double-blind, placebo-controlled trial of a 1500 mg/d calcium supplement taken over a 12-wk period, the mean arterial pressure of normotensive adult males (n = 37) was modestly but significantly lowered as compared with a placebo group (n = 38). Within the Ca group only, responders (greater than or equal to 5 mm Hg decrease in mean arterial pressure, n = 14) were compared with nonresponders (less than 5 mm Hg decrease in mean arterial pressure, n = 23). The responders were older (p = 0.002) and exhibited higher mean arterial pressure (p = 0.00001), higher serum parathyroid hormone (p = 0.01), and lower serum total Ca (p = 0.001) at baseline. A stepwise discriminant function analysis revealed that mean arterial pressure and serum total Ca correctly classified 78.38% of the responders and nonresponders and, thus, were the most important determinants of blood pressure response to supplemental Ca.

This article has been cited by other articles:

				H. C. Bucher, R. J. Cook, G. H. Guyatt, J. D. Lang, D. J. Cook, R. Hatala, and D. L. Hunt Effects of Dietary Calcium Supplementation on Blood Pressure: A Meta-analysis of Randomized Controlled Trials JAMA, April 3, 1996; 275(13): 1016 - 1022. [Abstract] [PDF]