AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shepherd, R. W.
Right arrow Articles by Francis, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shepherd, R. W.
Right arrow Articles by Francis, P.
Agricola
Right arrow Articles by Shepherd, R. W.
Right arrow Articles by Francis, P.

American Journal of Clinical Nutrition, Vol 48, 235-239, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Short-term nutritional supplementation during management of pulmonary exacerbations in cystic fibrosis: a controlled study, including effects of protein turnover

RW Shepherd, TL Holt, G Cleghorn, LC Ward, A Isles and P Francis
Division of Paediatric Gastroenterology and Nutrition, Royal Children's Hospital, Brisbane, Australia.

Effects of nutritional supplements on minimizing weight loss and abnormalities of protein turnover during pulmonary exacerbations in cystic fibrosis (CF) were studied by controlled trial. Patients received pulmonary therapy and either standard diet (n = 10) or adjunctive enteral supplements (n = 12). Initial protein turnover, measured by [15N]glycine kinetics, showed alterations of protein synthesis (P Syn) and catabolism (P Cat), which correlated with the degree of underweight, and negligible net protein deposition (P Dep). With treatment both groups had significant increases in mean body weight and forced expiratory volume in 1 s, expressed as percent predicted value for height (FEV1) by 3 wk, but a significant correlation between initial underweight and subsequent weight gain was observed only in supplemented patients. Mean P Syn and P Dep increased significantly (p less than 0.001) only in the supplemented group. Pulmonary exacerbations in CF have important adverse effects on body- protein metabolism, similar to changes in protein-energy malnutrition and infection. These effects are reversed by short-term nutritional support. Strategic nutritional intervention should thus be considered in management, especially in malnourished patients.


This article has been cited by other articles:


Home page
 ThoraxHome page
S. C Bell and P. J Robinson
Exacerbations in cystic fibrosis: 2 {middle dot} Prevention
Thorax, August 1, 2007; 62(8): 723 - 732.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
V. G. Geukers, J. H Oudshoorn, J. A. Taminiau, C. K van der Ent, P. Schilte, A. F. Ruiter, M. T Ackermans, E. Endert, C. F Jonkers-Schuitema, H. S. Heymans, et al.
Short-term protein intake and stimulation of protein synthesis in stunted children with cystic fibrosis
Am. J. Clinical Nutrition, March 1, 2005; 81(3): 605 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
P Vic, S Ategbo, F Gottrand, V Launay, G A Loeuille, J C Elian, D Druon, J P Farriaux, and D Turck
Nutritional impact of antipseudomonas intravenous antibiotic courses in cystic fibrosis
Arch. Dis. Child., May 1, 1997; 76(5): 437 - 440.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by The American Society for Nutrition