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American Journal of Clinical Nutrition, Vol 48, 612-619, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Safety of oral intake of vitamin E

A Bendich and LJ Machlin
Clinical Nutrition, Hoffman-La Roche Inc, Nutley, NJ 07110.

A review of the literature concerning the safety of oral intake of vitamin E indicated that the toxicity of vitamin E is low. Vitamin E supplementation has resulted in inconsistent effects in serum lipid and lipoprotein levels. Animal studies showed that vitamin E is not mutagenic, carcinogenic, or teratogenic. In human studies with double- blind protocols and in large population studies, oral vitamin E supplementation resulted in few side effects even at doses as high as 3200 mg/d (3200 IU/d).


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