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American Journal of Clinical Nutrition, Vol 48, 1400-1402, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Increased plasma carnitine in trauma patients given lipid-supplemented total parenteral nutrition

AT Davis, RM Albrecht, DJ Scholten and RE Morgan
Department of Surgery, Michigan State University, Grand Rapids.

The purpose of this study was to determine the effects of altering the fuel substrate mix of total parenteral nutrition (TPN) on plasma and urinary carnitine in trauma patients. TPN solutions were either 100% carbohydrate (CHO) based or lipid based (70% CHO, 30% lipid). There were statistically significant (p less than 0.05) increases in plasma levels of free carnitine, short-chain acyl carnitine, and total carnitine in trauma patients receiving lipid-based TPN. No significant differences in urinary carnitine excretion were noted between groups. We conclude that the use of lipids in the TPN of trauma patients leads to an alteration in plasma carnitine metabolism.




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Copyright © 1988 by The American Society for Nutrition