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American Journal of Clinical Nutrition, Vol 48, 1431-1435, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Vitamin A treatment of sexual dysfunction in male alcoholics

TM Worner, GG Gordon, MA Leo and CS Lieber
Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, NY 10468.

Thirty abstinent male alcoholics with sexual dysfunction were randomized to treatment with 3 mg RE (10,000 IU) vitamin A or placebo daily for 4 mo. Age, drinking history, period of abstinence before enrollment, and base-line laboratory indices were comparable in both groups at entry. Of the 15 subjects given placebo, 13 had a partial or full recovery of sexual functioning. By contrast, of those given vitamin A, 10 had a partial response. There were no complete responders. Six subjects (1 placebo, 5 vitamin A) who developed liver abnormalities during treatment underwent liver biopsies; five had fibrosis or cirrhosis. A significant decrease in luteinizing hormone was noted in the group given vitamin A compared with the placebo- treated group. Thus vitamin A therapy did not improve sexual functioning in male alcoholics and may have been associated with toxicity.




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