AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mascioli, E. A.
Right arrow Articles by Blackburn, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mascioli, E. A.
Right arrow Articles by Blackburn, G. L.
Agricola
Right arrow Articles by Mascioli, E. A.
Right arrow Articles by Blackburn, G. L.

American Journal of Clinical Nutrition, Vol 49, 277-282, Copyright © 1989 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Endotoxin challenge after menhaden oil diet: effects on survival of guinea pigs

EA Mascioli, Y Iwasa, S Trimbo, L Leader, BR Bistrian and GL Blackburn
Department of Medicine and Surgery, Harvard Medical School, New England Deaconess Hospital, Boston, MA 02215.

Improvement in survival to endotoxin has been seen after pretreatment with cyclooxygenase inhibitors. Because eicosapentaenoic acid (EPA), found in menhaden oil, competitively inhibits cyclooxygenase, we fed two groups of guinea pigs diets, in which the fat source was either menhaden or safflower oil, for 6 wk. A third group was allowed the safflower oil diet ad libitum. Menhaden oil-fed animals showed enhanced survival compared with safflower oil control animals 20 h after endotoxin (87 vs 63%, p less than 0.05). Ad libitum-fed safflower oil animals survived least well, with 47% alive at 20 h (p less than 0.005 vs menhaden oil group). We conclude that feeding animals a diet whose predominant lipid source is fish oil significantly improves survival after endotoxin. Dietary fat should be viewed not only as a caloric source but as a pharmacologically active substance that can have profound effects on the host's response to toxic insults.


This article has been cited by other articles:


Home page
 J DAIRY SCIHome page
M. A. Ballou, G. D. Cruz, W. Pittroff, D. H. Keisler, and E. J. DePeters
Modifying the Acute Phase Response of Jersey Calves by Supplementing Milk Replacer with Omega-3 Fatty Acids from Fish Oil
J Dairy Sci, September 1, 2008; 91(9): 3478 - 3487.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
T. B. Farran, C. D. Reinhardt, D. A. Blasi, J. E. Minton, T. H. Elsasser, J. J. Higgins, and J. S. Drouillard
Source of dietary lipid may modify the immune response in stressed feeder cattle
J Anim Sci, June 1, 2008; 86(6): 1382 - 1394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
G. J. Wanten and P. C Calder
Immune modulation by parenteral lipid emulsions
Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1171 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
M. A. Puertollano, L. Cruz-Chamorro, E. Puertollano, M. T. Perez-Toscano, G. Alvarez de Cienfuegos, and M. A. de Pablo
Assessment of Interleukin-12, Gamma Interferon, and Tumor Necrosis Factor Alpha Secretion in Sera from Mice Fed with Dietary Lipids during Different Stages of Listeria monocytogenes Infection
Clin. Vaccine Immunol., September 1, 2005; 12(9): 1098 - 1103.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. Yang and M. E. Cook
Dietary Conjugated Linoleic Acid Decreased Cachexia, Macrophage Tumor Necrosis Factor-{alpha} Production, and Modifies Splenocyte Cytokines Production
Experimental Biology and Medicine, January 1, 2003; 228(1): 51 - 58.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by The American Society for Nutrition