American Journal of Clinical Nutrition, Vol 49, 448-456, Copyright © 1989 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Linoleic-acid-enriched diet: long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin- dependent diabetic patients

RJ Heine, C Mulder, C Popp-Snijders, J van der Meer and EA van der Veen
Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands.

Long-term (30 wk) effects on serum lipoproteins and insulin sensitivity of two diets, one with a low polyunsaturated to saturated fat ratio (P:S 0.3) and one with a P:S of 1.0, were compared in 14 patients with noninsulin-dependent diabetes mellitus (NIDDM) in a crossover study. Total and LDL-cholesterol levels declined by 7.6% (p less than 0.01) and 9.8% (p less than 0.01), respectively, during the high P:S diet. VLDL-, HDL2-, and HDL3-cholesterol; triacylglycerol; and apolipoprotein A1, A2, and B levels were not affected by the change in P:S. Despite a modest increase of insulin-mediated glucose disposal at physiologic insulinemia during the high P:S diet, no influence was seen on glycemic control, and on blood glucose, plasma insulin, and C peptide responses to mixed meals. In conclusion, a linoleic-enriched diet in patients with NIDD causes a less atherogenic lipoprotein profile but does not influence glycemic control and carbohydrate tolerance.

This article has been cited by other articles:

				A. M Zivkovic, J B. German, and A. J Sanyal Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease Am. J. Clinical Nutrition, August 1, 2007; 86(2): 285 - 300. [Abstract] [Full Text] [PDF]

				K. McAuley and J. Mann Thematic review series: Patient-Oriented Research. Nutritional determinants of insulin resistance J. Lipid Res., August 1, 2006; 47(8): 1668 - 1676. [Abstract] [Full Text] [PDF]

				J. S. Lee, S. K. Pinnamaneni, S. J. Eo, I. H. Cho, J. H. Pyo, C. K. Kim, A. J. Sinclair, M. A. Febbraio, and M. J. Watt Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites J Appl Physiol, May 1, 2006; 100(5): 1467 - 1474. [Abstract] [Full Text] [PDF]

				R. Jiang, J. E. Manson, M. J. Stampfer, S. Liu, W. C. Willett, and F. B. Hu Nut and Peanut Butter Consumption and Risk of Type 2 Diabetes in Women JAMA, November 27, 2002; 288(20): 2554 - 2560. [Abstract] [Full Text] [PDF]

				M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al. Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications Diabetes Care, January 1, 2002; 25(1): 148 - 198. [Full Text] [PDF]

				J. Salmeron, F. B Hu, J. E Manson, M. J Stampfer, G. A Colditz, E. B Rimm, and W. C Willett Dietary fat intake and risk of type 2 diabetes in women Am. J. Clinical Nutrition, June 1, 2001; 73(6): 1019 - 1026. [Abstract] [Full Text] [PDF]