AJCN Tufts Nutrition Symposium, Boston & Online Sept 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pasatiempo, A. M.
Right arrow Articles by Ross, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pasatiempo, A. M.
Right arrow Articles by Ross, A. C.
Agricola
Right arrow Articles by Pasatiempo, A. M.
Right arrow Articles by Ross, A. C.

American Journal of Clinical Nutrition, Vol 49, 501-510, Copyright © 1989 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Vitamin A depletion and repletion: effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III)

AM Pasatiempo, TA Bowman, CE Taylor and AC Ross
Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129.

To determine the ability of young rats to produce antibody against pneumococcal polysaccharide (SSS-III), weaning rats were fed a semipurified diet containing no retinol (A-) or 4 micrograms retinol/g diet (A+). Splenic antibody response specific to SSS-III was 17% (p less than or equal to 0.05) of control for A- Sprague-Dawley rats; similarly, the response of retinol-depleted Lewis rats was 22% (p less than or equal to 0.05) of pair-fed controls. No kinetic differences were observed in the antibody response between A- and control Lewis rats. Retinol depletion more markedly reduced the antibody response of male rats than female rats despite equally low tissue retinol concentrations. For both strains, retinol repletion near the time of immunization normalized antibody production. When male Lewis rats were fed the A- diet longer, the antibody response of A- rats was only 3% of pair-fed controls; repletion again normalized antibody production. Thus, retinol supplementation near the time of immunization can restore the immune response in previously compromised A- rats.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
D. Cui, Z. Moldoveanu, and C. B. Stephensen
High-Level Dietary Vitamin A Enhances T-Helper Type 2 Cytokine Production and Secretory Immunoglobulin A Response to Influenza A Virus Infection in BALB/c Mice
J. Nutr., May 1, 2000; 130(5): 1132 - 1139.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
M. M. Rahman, D. Mahalanabis, S. Hossain, M. A. Wahed, J. O. Alvarez, G. R. Siber, C. Thompson, M. Santosham, and G. J. Fuchs
Simultaneous Vitamin A Administration at Routine Immunization Contact Enhances Antibody Response to Diphtheria Vaccine in Infants Younger than Six Months
J. Nutr., December 1, 1999; 129(12): 2192 - 2195.
[Abstract] [Full Text]

Home page
 Arch Pediatr Adolesc MedHome page
T. R. Frieden, A. L. Sowell, K. J. Henning, D. L. Huff, and R. A. Gunn
Vitamin A Levels and Severity of Measles: New York City
Arch Pediatr Adolesc Med, February 1, 1992; 146(2): 182 - 186.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by The American Society for Nutrition