| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 49, 713-716, Copyright © 1989 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
HC Furr, O Amedee-Manesme, AJ Clifford, HR Bergen 3d, AD Jones, DP Anderson and JA Olson
Department of Biochemistry and Biophysics, Iowa State University, Ames 50011.
The vitamin A status in 11 generally healthy surgical patients was estimated by measuring the dilution of a 45-mg oral dose of tetradeuterated retinyl acetate (99% pure). After purification of retinol by high-performance liquid chromatography, the ratio of 2H4- retinol:1H-retinol in plasma was measured by gas chromatography-mass spectrometry. On the basis of the observed ratios of [2H4]retinol:[1H]retinol over 19-47 d, the total body reserves and liver concentrations of vitamin A were calculated. Liver biopsy samples taken at surgery were directly analyzed for vitamin A. The correlation coefficient between calculated and measured liver vitamin A concentrations for 10 of the subjects was 0.88, and the Spearman's rank correlation coefficient was 0.95 (p less than 0.002). Thus, total body reserves of vitamin A in humans can be estimated validly in the marginal and satisfactory ranges by a benign, relatively noninvasive procedure.
This article has been cited by other articles:
|
|
 |
|
  A. L. Escaron, M. H. Green, J. A. Howe, and S. A. Tanumihardjo Mathematical Modeling of Serum 13C-Retinol in Captive Rhesus Monkeys Provides New Insights on Hypervitaminosis A J. Nutr., October 1, 2009; 139(10): 2000 - 2006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Ho, F. F. de Moura, S.-H. Kim, B. J. Burri, and A. J. Clifford A Minute Dose of 14C-{beta}-Carotene Is Absorbed and Converted to Retinoids in Humans J. Nutr., August 1, 2009; 139(8): 1480 - 1486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Howe, A. R. Valentine, A. K. Hull, and S. A. Tanumihardjo 13C Natural Abundance in Serum Retinol Acts as a Biomarker for Increases in Dietary Provitamin A Experimental Biology and Medicine, February 1, 2009; 234(2): 140 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Ahmad, M. J. Haskell, R. Raqib, and C. B. Stephensen Markers of Innate Immune Function Are Associated with Vitamin A Stores in Men J. Nutr., February 1, 2009; 139(2): 377 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Ahmad, M. J. Haskell, R. Raqib, and C. B. Stephensen Men with Low Vitamin A Stores Respond Adequately to Primary Yellow Fever and Secondary Tetanus Toxoid Vaccination J. Nutr., November 1, 2008; 138(11): 2276 - 2283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Cifelli, J. B. Green, Z. Wang, S. Yin, R. M. Russell, G. Tang, and M. H. Green Kinetic Analysis Shows that Vitamin A Disposal Rate in Humans Is Positively Correlated with Vitamin A Stores J. Nutr., May 1, 2008; 138(5): 971 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Ross and N.-q. Li Lung Retinyl Ester Is Low in Young Adult Rats Fed a Vitamin A Deficient Diet after Weaning, despite Neonatal Vitamin A Supplementation and Maintenance of Normal Plasma Retinol J. Nutr., October 1, 2007; 137(10): 2213 - 2218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D Ribaya-Mercado, C. C Maramag, L. W Tengco, G. G Dolnikowski, J. B Blumberg, and F. S Solon Carotene-rich plant foods ingested with minimal dietary fat enhance the total-body vitamin A pool size in Filipino schoolchildren as assessed by stable-isotope-dilution methodology Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1041 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K Tchum, S. A Tanumihardjo, S. Newton, B. de Benoist, S. Owusu-Agyei, F. K. Arthur, and A. Tetteh Evaluation of vitamin A supplementation regimens in Ghanaian postpartum mothers with the use of the modified-relative-dose-response test Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1344 - 1349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L Penniston and S. A Tanumihardjo The acute and chronic toxic effects of vitamin A Am. J. Clinical Nutrition, February 1, 2006; 83(2): 191 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Haskell and K. H Brown Reply to M van Lieshout and S de Pee Am. J. Clinical Nutrition, April 1, 2005; 81(4): 945 - 946. [Full Text] [PDF]
|
|
|
|
|
|
J. D Ribaya-Mercado, N. W Solomons, Y. Medrano, J. Bulux, G. G Dolnikowski, R. M Russell, and C. B Wallace Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1291 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Haskell, K. M Jamil, F. Hassan, J. M Peerson, M I. Hossain, G. J Fuchs, and K. H Brown Daily consumption of Indian spinach (Basella alba) or sweet potatoes has a positive effect on total-body vitamin A stores in Bangladeshi men Am. J. Clinical Nutrition, September 1, 2004; 80(3): 705 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D Ribaya-Mercado, F. S Solon, L. S Fermin, C. S Perfecto, J. A. A Solon, G. G Dolnikowski, and R. M Russell Dietary vitamin A intakes of Filipino elders with adequate or low liver vitamin A concentrations as assessed by the deuterated-retinol-dilution method: implications for dietary requirements Am. J. Clinical Nutrition, April 1, 2004; 79(4): 633 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Tanumihardjo Assessing Vitamin A Status: Past, Present and Future J. Nutr., January 1, 2004; 134(1): 290S - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Lemke, S. R. Dueker, J. R. Follett, Y. Lin, C. Carkeet, B. A. Buchholz, J. S. Vogel, and A. J. Clifford Absorption and retinol equivalence of {beta}-carotene in humans is influenced by dietary vitamin A intake J. Lipid Res., August 1, 2003; 44(8): 1591 - 1600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Haskell, J. L Lembcke, M. Salazar, M. H Green, J. M Peerson, and K. H Brown Population-based plasma kinetics of an oral dose of [2H4]retinyl acetate among preschool-aged, Peruvian children Am. J. Clinical Nutrition, March 1, 2003; 77(3): 681 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D Ribaya-Mercado, F. S Solon, G. E Dallal, N. W Solomons, L. S Fermin, M. Mazariegos, G. G Dolnikowski, and R. M Russell Quantitative assessment of total body stores of vitamin A in adults with the use of a 3-d deuterated-retinol-dilution procedure Am. J. Clinical Nutrition, March 1, 2003; 77(3): 694 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Lieshout, C. E West, and R. B van Breemen Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly {beta}-carotene, in humans: a review Am. J. Clinical Nutrition, January 1, 2003; 77(1): 12 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Rosales, K. K. Chau, M. H. Haskell, and A. H. Shankar Determination of a Cut-Off Value for the Molar Ratio of Retinol-Binding Protein to Transthyretin (RBP:TTR) in Bangladeshi Patients with Low Hepatic Vitamin A Stores J. Nutr., December 1, 2002; 132(12): 3687 - 3692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Allen and M. Haskell Estimating the Potential for Vitamin A Toxicity in Women and Young Children J. Nutr., September 1, 2002; 132(9): 2907S - 2919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Tang, J. Qin, L.-y. Hao, S.-a. Yin, and R. M Russell Use of a short-term isotope-dilution method for determining the vitamin A status of children Am. J. Clinical Nutrition, August 1, 2002; 76(2): 413 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Tanumihardjo and K. L. Penniston Simplified methodology to determine breast milk retinol concentrations J. Lipid Res., February 1, 2002; 43(2): 350 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Penniston and S. A. Tanumihardjo Subtoxic Hepatic Vitamin A Concentrations in Captive Rhesus Monkeys (Macaca mulatta) J. Nutr., November 1, 2001; 131(11): 2904 - 2909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J Edwards, C.-S. You, J. E Swanson, and R. S Parker A novel extrinsic reference method for assessing the vitamin A value of plant foods Am. J. Clinical Nutrition, September 1, 2001; 74(3): 348 - 355. [Abstract] [Full Text]
|
|
|
|
|
|
S. A. Tanumihardjo Vitamin A Status Assessment in Rats with 13C4-Retinyl Acetate and Gas Chromatography/Combustion/Isotope Ratio Mass Spectrometry J. Nutr., November 1, 2000; 130(11): 2844 - 2849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D Ribaya-Mercado, F. S Solon, M. A Solon, M. A Cabal-Barza, C. S Perfecto, G. Tang, J. A. A Solon, C. R Fjeld, and R. M Russell Bioconversion of plant carotenoids to vitamin A in Filipino school-aged children varies inversely with vitamin A status Am. J. Clinical Nutrition, August 1, 2000; 72(2): 455 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lin, S. R Dueker, B. J Burri, T. R Neidlinger, and A. J Clifford Variability of the conversion of {beta}-carotene to vitamin A in women measured by using a double-tracer study design Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1545 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Tang, X.-f. Gu, S.-m. Hu, Q.-m. Xu, J. Qin, G. G Dolnikowski, C. R Fjeld, X. Gao, R. M Russell, and S.-a. Yin Green and yellow vegetables can maintain body stores of vitamin A in Chinese children Am. J. Clinical Nutrition, December 1, 1999; 70(6): 1069 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Haskell, R. N Mazumder, J. M Peerson, A D. Jones, M. A Wahed, D. Mahalanabis, and K. H Brown Use of the deuterated-retinol-dilution technique to assess total-body vitamin A stores of adult volunteers consuming different amounts of vitamin A Am. J. Clinical Nutrition, November 1, 1999; 70(5): 874 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sibulesky, K. Hayes, A. Pronczuk, C. Weigel-DiFranco, B. Rosner, and E. L Berson Safety of <7500 RE (<25000 IU) vitamin A daily in adults with retinitis pigmentosa Am. J. Clinical Nutrition, April 1, 1999; 69(4): 656 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Olson Correcting for vitamin A turnover in isotopedilution studies Am. J. Clinical Nutrition, March 1, 1999; 69(3): 576 - 577. [Full Text]
|
|
|
|
|
|
J. A. Olson Vitamin A assessment by the isotope-dilution technique: good news from Guatemala Am. J. Clinical Nutrition, February 1, 1999; 69(2): 177 - 178. [Full Text] [PDF]
|
|
|
|
|
|
J. D Ribaya-Mercado, M. Mazariegos, G. Tang, M. E. Romero-Abal, I. Mena, N. W Solomons, and R. M Russell Assessment of total body stores of vitamin A in Guatemalan elderly by the deuterated-retinol-dilution method Am. J. Clinical Nutrition, February 1, 1999; 69(2): 278 - 284. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
