American Journal of Clinical Nutrition, Vol 49, 1217-1227, Copyright © 1989 by The American Society for Clinical Nutrition, Inc

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Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein

EJ Masoro, K Iwasaki, CA Gleiser, CA McMahan, EJ Seo and BP Yu
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.

Chronic nephropathy involving glomerular sclerosis markedly progresses in severity with age in male Fischer 344 rats fed ad libitum. Restricting food intake by 40% almost totally prevents progression of these lesions. Restricting food intake by 40% without restricting protein intake is also highly effective although somewhat less so than food restriction that includes protein restriction. These findings indicate that reducing the intake of protein is not the major reason for the retardation by food restriction of the age-associated progression of nephropathy in rats.

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