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American Journal of Clinical Nutrition, Vol 5, 377-380, Copyright © 1957 by The American Society for Clinical Nutrition, Inc.

The Effect of Liver Disease on Adrenal Cortical Function

FRANK H. TYLER M.D.1

1 From the Laboratory for the Study of Hereditary and Metabolic Disorders, Department of Medicine, University of Utah, College of Medicine, Salt Lake City

Study of patients with cirrhosis of the liver has demonstrated that the plasma levels of 17-hydroxycorticosteroid are normal. However, there is a reduced rate of removal of cortisol from the plasma and therefore less secretion is required to maintain these normal levels.

In the postoperative patients the 17-hydroxycorticosteroid levels rose strikingly. It appears that this change was mediated in part by hepatic dysfunction and in part by stimulation of the adrenal to secrete 17-hydroxycorticosteroids at sub-maximal rates.

In the evaluation of adrenal cortical function, it is important that the status of hepatic function be considered.






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Copyright © 1957 by The American Society for Nutrition