American Journal of Clinical Nutrition, Vol 50, 1008-1014, Copyright © 1989 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch

S Reiser, AS Powell, DJ Scholfield, P Panda, M Fields and JJ Canary
Beltsville Human Nutrition Research Center, US Department of Agriculture, MD 20705.

Ten hyperinsulinemic and 11 nonhyperinsulinemic men consumed a typical American diet containing 20% of calories either as fructose or as high- amylose cornstarch for 5 wk in a crossover design to determine their effects on indices of glucose tolerance. Blood glucose, insulin, and fructose were determined before and 30, 60, 90, 120 and 180 min after breakfast, lunch, and dinner. Glucose responses were significantly lower 60 and 120 min and the insulin response lower 60 min after the meals containing fructose. Hyperinsulinemic men showed a tendency toward decreased insulin sensitivity after consuming fructose on the basis of an increased insulin-to-glucose ratio and decreased insulin binding to erythrocytes. These results generally show a beneficial effect of fructose on glucose tolerance; however, recommendations for including large amounts of fructose in the diet should also be based on a complete evaluation of the effect on other metabolic risk factors.

This article has been cited by other articles:

				K. L. Stanhope and P. J. Havel Fructose Consumption: Considerations for Future Research on Its Effects on Adipose Distribution, Lipid Metabolism, and Insulin Sensitivity in Humans J. Nutr., June 1, 2009; 139(6): 1236S - 1241S. [Abstract] [Full Text] [PDF]

				K. L Stanhope, S. C Griffen, B. R Bair, M. M Swarbrick, N. L Keim, and P. J Havel Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1194 - 1203. [Abstract] [Full Text] [PDF]

				L. Cordain, S B. Eaton, A. Sebastian, N. Mann, S. Lindeberg, B. A Watkins, J. H O'Keefe, and J. Brand-Miller Origins and evolution of the Western diet: health implications for the 21st century Am. J. Clinical Nutrition, February 1, 2005; 81(2): 341 - 354. [Abstract] [Full Text] [PDF]

				T. Wu, E. Giovannucci, T. Pischon, S. E Hankinson, J. Ma, N. Rifai, and E. B Rimm Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women Am. J. Clinical Nutrition, October 1, 2004; 80(4): 1043 - 1049. [Abstract] [Full Text] [PDF]

				S.-J. Janket, J. E. Manson, H. Sesso, J. E. Buring, and S. Liu A Prospective Study of Sugar Intake and Risk of Type 2 Diabetes in Women Diabetes Care, April 1, 2003; 26(4): 1008 - 1015. [Abstract] [Full Text] [PDF]

				S. S Elliott, N. L Keim, J. S Stern, K. Teff, and P. J Havel Fructose, weight gain, and the insulin resistance syndrome Am. J. Clinical Nutrition, November 1, 2002; 76(5): 911 - 922. [Abstract] [Full Text] [PDF]

				J. M. Talbot Guidelines for the Scientific Review of Enteral Food Products for Special Medical Purposes JPEN J Parenter Enteral Nutr, May 1, 1991; 15(3_suppl): i - E-2. [PDF]