| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 51, 225-227, Copyright © 1990 by The American Society for Clinical Nutrition, Inc
REVIEW ARTICLES |
GJ Fosmire
Department of Nutrition, College of Health and Human Development, Penn State University, University Park 16802.
Although consequences of zinc deficiency have been recognized for many years, it is only recently that attention has been directed to the potential consequences of excessive zinc intake. This is a review of the literature on manifestations of toxicity at several levels of zinc intake. Zinc is considered to be relatively nontoxic, particularly if taken orally. However, manifestations of overt toxicity symptoms (nausea, vomiting, epigastric pain, lethargy, and fatigue) will occur with extremely high zinc intakes. At low intakes, but at amounts well in excess of the Recommended Dietary Allowance (RDA) (100-300 mg Zn/d vs an RDA of 15 mg Zn/d), evidence of induced copper deficiency with attendant symptoms of anemia and neutropenia, as well as impaired immune function and adverse effects on the ratio of low-density- lipoprotein to high-density-lipoprotein (LDL/HDL) cholesterol have been reported. Even lower levels of zinc supplementation, closer in amount to the RDA, have been suggested to interfere with the utilization of copper and iron and to adversely affect HDL cholesterol concentrations. Individuals using zinc supplements should be aware of the possible complications attendant to their use.
This article has been cited by other articles:
|
|
 |
|
  D. Zheng, G. P. Feeney, P. Kille, and C. Hogstrand Regulation of ZIP and ZnT zinc transporters in zebrafish gill: zinc repression of ZIP10 transcription by an intronic MRE cluster Physiol Genomics, July 9, 2008; 34(2): 205 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Thompson and M. P. Fuhrman Nutrients and Wound Healing: Still Searching for the Magic Bullet Nutr Clin Pract, June 1, 2005; 20(3): 331 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Chernoff Micronutrient requirements in older women Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1240S - 1245S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Mares, T. L. La Rowe, and B. A. Blodi Doctor, What Vitamins Should I Take for My Eyes? Arch Ophthalmol, April 1, 2004; 122(4): 628 - 635. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lim, M. Levy, and T. M. Bray Dietary Zinc Alters Early Inflammatory Responses during Cutaneous Wound Healing in Weanling CD-1 Mice J. Nutr., April 1, 2004; 134(4): 811 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N Ames, I. Elson-Schwab, and E. A Silver High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms Am. J. Clinical Nutrition, April 1, 2002; 75(4): 616 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lee, M. M. O. Pena, Y. Nose, and D. J. Thiele Biochemical Characterization of the Human Copper Transporter Ctr1 J. Biol. Chem., February 1, 2002; 277(6): 4380 - 4387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ma and N. M. Betts Zinc and Copper Intakes and Their Major Food Sources for Older Adults in the 1994-96 Continuing Survey of Food Intakes by Individuals (CSFII) J. Nutr., November 1, 2000; 130(11): 2838 - 2843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Baum, G. Shor-Posner, and A. Campa Zinc Status in Human Immunodeficiency Virus Infection J. Nutr., May 1, 2000; 130(5): 1421S - 1423. [Abstract] [Full Text]
|
|
|
|
|
|
E. Mocchegiani and M. Muzzioli Therapeutic Application of Zinc in Human Immunodeficiency Virus against Opportunistic Infections J. Nutr., May 1, 2000; 130(5): 1424S - 1431. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
