AJCN Tufts Nutrition Symposium, Boston Sept 24-26
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuvibidila, S.
Right arrow Articles by Lepault, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuvibidila, S.
Right arrow Articles by Lepault, F.
Agricola
Right arrow Articles by Kuvibidila, S.
Right arrow Articles by Lepault, F.

American Journal of Clinical Nutrition, Vol 51, 228-232, Copyright © 1990 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Influence of iron-deficiency anemia on selected thymus functions in mice: thymulin biological activity, T-cell subsets, and thymocyte proliferation

S Kuvibidila, M Dardenne, W Savino and F Lepault
INSERM U-1. Unite de Recherches sur la Nutrition et l'Alimentation, Hopital Bichat, Paris, France.

To define the effects of iron deficiency on thymulin biological activity, T-cell subsets, and thymocyte proliferation, C57BL/6 female mice at weaning were fed an iron-deficient diet (10 mg Fe/kg diet), an iron-sufficient diet (50 mg Fe/kg diet), or restricted amounts of the iron-sufficient diet (the pair-fed group) for 40 d. Iron deficiency did not reduce the concentration of either serum or intracytoplasmic thymulin. Although T-cell subsets in the thymus were not altered, both the cortical and medullar regions were depleted of thymocytes. In the spleen iron deficiency (but not underfeeding) significantly reduced the percentage of L3T4+ cells, of Lyt-2+ cells, and thus of the overall T- cell population. However, it did not affect the ratio of L3T4+ to Lyt- 2+ T cells. Thymocyte proliferation was significantly reduced at the concanavalin A (Con A) dose (10 mg/L) that produced maximal stimulation in control and pair-fed mice but not at low (7.5 mg/L) or high (15 mg/L) Con A concentrations. We conclude that the impairment in immune functions associated with iron deficiency is not due to an impairment in thymic endocrine function but rather to decreased immunocompetent lymphocytes.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. Fagoonee, C. Caorsi, M. Giovarelli, M. Stoltenberg, L. Silengo, F. Altruda, G. Camussi, E. Tolosano, and B. Bussolati
Lack of Plasma Protein Hemopexin Dampens Mercury-Induced Autoimmune Response in Mice
J. Immunol., August 1, 2008; 181(3): 1937 - 1947.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. R. Kuvibidila, B. S. Baliga, R. P. Warrier, and R. M. Suskind
Iron Deficiency Reduces the Hydrolysis of Cell Membrane Phosphatidyl Inositol-4,5-Bisphosphate during Splenic Lymphocyte Activation in C57BL/6 Mice
J. Nutr., July 1, 1998; 128(7): 1077 - 1083.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. D. Potter, S. G. Shinpock, R. A. Popp, D. M. Popp, V. Godfrey, D. A. Carpenter, A. Bernstein, D. K. Johnson, and E. M. Rinchik
Mutations in the Murine Fitness 1 Gene Result in Defective Hematopoiesis
Blood, September 1, 1997; 90(5): 1850 - 1857.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by The American Society for Nutrition