| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 51, 685-689, Copyright © 1990 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
MJ Koruda, RH Rolandelli, DZ Bliss, J Hastings, JL Rombeau and RG Settle
Department of Surgery, University of Pennsylvania, Philadelphia.
When enteral nutrition is excluded from animals maintained solely with total parenteral nutrition (TPN), atrophy of the intestinal mucosa is observed. Short-chain fatty acids (SCFAs) are produced in the colon by the fermentation of dietary carbohydrates and fiber polysaccharides and have been shown to stimulate mucosal-cell mitotic activity in the intestine. This study compared the effects of an intravenous and an intracecal infusion of SCFAs on the small-bowel mucosa. Rats received standard TPN, TPN with SCFAs (sodium acetate, propionate, and butyrate), TPN with an intracecal infusion of SCFAs, or rat food. After 7 d jejunal and ileal mucosal weights, DNA, RNA, and protein were determined. Standard TPN produced significant atrophy of the jejunal and ileal mucosa. Both the intracecal and intravenous infusion of SCFAs significantly reduced the mucosal atrophy associated with TPN. The intravenous and intracolonic infusion of SCFAs were equally effective in inhibiting small-bowel mucosal atrophy.
This article has been cited by other articles:
|
|
 |
|
  L. Peng, Z.-R. Li, R. S. Green, I. R. Holzman, and J. Lin Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers J. Nutr., September 1, 2009; 139(9): 1619 - 1625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Saberi, S. A. Stewart, M. Annette, A. L. Knowles, D. Attaix, and S. E. Samuels Effect of Energy Substrates on Protein Degradation in Isolated Small Intestinal Enterocytes From Rats JPEN J Parenter Enteral Nutr, November 1, 2006; 30(6): 497 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Tappenden, D. M. Albin, A. L. Bartholome, and H. F. Mangian Glucagon-Like Peptide-2 and Short-Chain Fatty Acids: A New Twist to an Old Story J. Nutr., November 1, 2003; 133(11): 3717 - 3720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Correa-Matos, S. M. Donovan, R. E. Isaacson, H. R. Gaskins, B. A. White, and K. A. Tappenden Fermentable Fiber Reduces Recovery Time and Improves Intestinal Function in Piglets Following Salmonella typhimurium Infection J. Nutr., June 1, 2003; 133(6): 1845 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nian, J. Gu, D. M. Irwin, and D. J. Drucker Human glucagon gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R173 - R183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Topping and P. M. Clifton Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides Physiol Rev, July 1, 2001; 81(3): 1031 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Beauvieux, P. Tissier, H. Gin, P. Canioni, and J.-L. Gallis Butyrate Impairs Energy Metabolism in Isolated Perfused Liver of Fed Rats J. Nutr., July 1, 2001; 131(7): 1986 - 1992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gross, R. Babst, A. Juretic, B. Herzog, P. Stehle, L. Filgueira, M. Oberholzer, F. Gudat, and M. Heberer Intralipid-Based Short-Term Total Parenteral Nutrition Does Not Impair Small Intestinal Mucosa-Related Cellular Immune Reactivity in the Healthy Rat JPEN J Parenter Enteral Nutr, November 1, 2000; 24(6): 337 - 344. [Abstract] [PDF]
|
|
|
|
|
|
N. M. Delzenne, N. Kok, P. Deloyer, and G. Dandrifosse Dietary Fructans Modulate Polyamine Concentration in the Cecum of Rats J. Nutr., October 1, 2000; 130(10): 2456 - 2460. [Abstract] [Full Text]
|
|
|
|
 |
|
 P B Jeppesen, B Hartmann, J Thulesen, B S Hansen, J J Holst, S S Poulsen, and P B Mortensen Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon Gut, September 1, 2000; 47(3): 370 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Thulesen, B Hartmann, C Nielsen, J J Holst, and S S Poulsen Diabetic intestinal growth adaptation and glucagon-like peptide 2 in the rat: effects of dietary fibre Gut, November 1, 1999; 45(5): 672 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ohta, Y. Motohashi, M. Ohtsuki, M. Hirayama, T. Adachi, and K. Sakuma Dietary Fructooligosaccharides Change the Concentration of Calbindin-D9k Differently in the Mucosa of the Small and Large Intestine of Rats J. Nutr., June 1, 1998; 128(6): 934 - 939. [Abstract] [Full Text]
|
|
|
|
|
|
S. Klein, D. H. Alters, R. J. Grand, M. S. Levin, H. C. Lin, C. M. Mansbach, C. Burant, P. Reeds, and J. L. Rombeau Advances in Nutrition and Gastroenterology: Summary of the 1997 A.S.P.E.N. Research Workshop JPEN J Parenter Enteral Nutr, January 1, 1998; 22(1): 3 - 13. [Abstract] [PDF]
|
|
|
|
|
|
E. Pouteau, H. Dumon, P. Nguyen, D. Darmaun, M. Champ, and M. Krempf Whole-Body, Peripheral and Intestinal Endogenous Acetate Turnover in Dogs Using Stable Isotopes J. Nutr., January 1, 1998; 128(1): 111 - 115. [Abstract] [Full Text]
|
|
|
|
|
|
J. Linseisen and G. Wolfram Efficacy of Different Triglycerides in Total Parenteral Nutrition for Preventing Atrophy of the Gut in Traumatized Rats JPEN J Parenter Enteral Nutr, January 1, 1997; 21(1): 21 - 26. [Abstract] [PDF]
|
|
|
|
|
|
J. S. Thompson, E. M. Qugley, J.M. Palmer, W. W. West, and T. E. Adrian Luminal Short-Chain Fatty Acids and Postresection Intestinal Adaptation JPEN J Parenter Enteral Nutr, September 1, 1996; 20(5): 338 - 343. [Abstract] [PDF]
|
|
|
|
|
|
K. A. Tappenden, A. B.R. Thomson, G. E. Wild, and M. I. McBurney Short-Chain Fatty Acids Increase Proglucagon and Ornithine Decarboxylase Messenger RNAs After Intestinal Resection in Rats JPEN J Parenter Enteral Nutr, September 1, 1996; 20(5): 357 - 362. [Abstract] [PDF]
|
|
|
|
|
|
V. C. Pratt, K. A. Tappenden, M. I. McBurney, and C. J. Field Short-Chain Fatty Acid-Supplemented Total Parenteral Nutrition Improves Nonspecific Immunity After Intestinal Resection in Rats JPEN J Parenter Enteral Nutr, July 1, 1996; 20(4): 264 - 271. [Abstract] [PDF]
|
|
|
|
|
|
J. W. Lynch, J. M. Miles, and J. W. Bailey Effects of the Short-Chain Triglyceride Triacetin on Intestinal Mucosa and Metabolic Substrates in Rats JPEN J Parenter Enteral Nutr, May 1, 1994; 18(3): 208 - 213. [Abstract] [PDF]
|
|
|
|
|
|
J. Linseisen and G. Wolfram Odd-Numbered Medium-Chain Triglycerides (Trinonanoin) in Total Parenteral Nutrition: Effects on Parameters of Fat Metabolism in Rabbits JPEN J Parenter Enteral Nutr, November 1, 1993; 17(6): 522 - 528. [Abstract] [PDF]
|
|
|
|
 |
|
 M. M. Gottschlich Invited Review: Selection of Optimal Lipid Sources in Enteral and Parenteral Nutrition Nutr Clin Pract, August 1, 1992; 7(4): 152 - 165. [Abstract] [PDF]
|
|
|
|
|
|
D. Friedel and G. M. Levine Effect of Short-Chain Fatty Acids on Colonic Function and Structure JPEN J Parenter Enteral Nutr, January 1, 1992; 16(1): 1 - 4. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Talbot Guidelines for the Scientific Review of Enteral Food Products for Special Medical Purposes JPEN J Parenter Enteral Nutr, May 1, 1991; 15(3_suppl): i - E-2. [PDF]
|
|
|
|
|
|
J. L. Rombeau and S. A. Kripke Metabolic and Intestinal Effects of Short-Chain Fatty Acids JPEN J Parenter Enteral Nutr, September 1, 1990; 14(5_suppl): 181S - 185S. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
