AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Snyder, D. K.
Right arrow Articles by Clemmons, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Snyder, D. K.
Right arrow Articles by Clemmons, D. R.
Agricola
Right arrow Articles by Snyder, D. K.
Right arrow Articles by Clemmons, D. R.

American Journal of Clinical Nutrition, Vol 52, 431-437, Copyright © 1990 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Anabolic effects of growth hormone in obese diet-restricted subjects are dose dependent

DK Snyder, LE Underwood and DR Clemmons
Department of Medicine, University of North Carolina, Chapel Hill.

In previous studies growth hormone (GH) injections [0.1 mg/kg ideal body wt (IBW) every other day] produced significant increases in plasma insulin-like growth factor I (IGF-I) concentrations and nitrogen retention, which were attenuated when 12 kcal/kg IBW was ingested. The present study was done to determine whether doubling the GH dose would enhance its anabolic effects and facilitate fat loss. Eight women (33- 83% over IBW) were fed 12 kcal/kg IBW for 14 wk. They received GH or vehicle injections, each for 5 wk during either weeks 2-6 or 9-13. GH improved nitrogen balance (GH, 3.6 +/- 123.2 mmol/d; vehicle, -132.0 +/- 117.9 mmol/d; means +/- SD; p less than 0.001). Plasma IGF-I increased from 32.1 +/- 9.6 to 79.4 +/- 22.1 nmol/L by day 5 of GH (p less than 0.001) and remained elevated until GH injections were discontinued. No significant effect of GH on mean body fat loss was observed. GH can induce significant anabolic responses even when caloric intake is decreased to 12 kcal/kg IBW. The degree and duration of these anabolic responses are dependent on the GH dose given.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
P. Lucidi, N. Parlanti, F. Piccioni, F. Santeusanio, and P. de Feo
Short-Term Treatment with Low Doses of Recombinant Human GH Stimulates Lipolysis in Visceral Obese Men
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3105 - 3109.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
G. A. Bray and F. L. Greenway
Current and Potential Drugs for Treatment of Obesity
Endocr. Rev., December 1, 1999; 20(6): 805 - 875.
[Abstract] [Full Text]

Home page
 J. Am. Coll. Nutr.Home page
A. Carrillo, R. Rising, R. Tverskaya, and F. Lifshitz
Effects of Exogenous Recombinant Human Growth Hormone on an Animal Model of Suboptimal Nutrition
J. Am. Coll. Nutr., June 1, 1998; 17(3): 276 - 281.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by The American Society for Nutrition