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American Journal of Clinical Nutrition, Vol 52, 572-577, Copyright © 1990 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Cardiomyopathy associated with nonendemic selenium deficiency in a Caucasian adolescent

G Lockitch, GP Taylor, LT Wong, AG Davidson, PJ Dison, D Riddell and B Massing
Department of Pathology, University of British Columbia, Vancouver, Canada.

We describe a girl aged 17 y who died after a cardiac arrest secondary to septic shock. At autopsy, the enlarged, soft, and flabby heart showed microscopic evidence of acute myocardial infarction, myocardial edema, myocardiocyte loss, replacement fibrosis in the interventricular septum, and right and left ventricular hypertrophic nucleomegaly. The pathological diagnosis was that of cardiomyopathy due to prolonged selenium deficiency. The patient had been on total parenteral nutrition for 17 mo, following extensive bowel resection for intractable pain, nausea, and vomiting caused by chronic idiopathic intestinal pseudoobstruction. Seven months before death, when severe biochemical selenium deficiency was diagnosed, supplemental selenium was added to the infusion, and plasma selenium concentrations increased. In long- standing selenium deficiency, sepsis may contribute the final insult to a damaged myocardium, triggering symptomatic cardiac failure and sudden death.


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