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American Journal of Clinical Nutrition, Vol 52, 602-609, Copyright © 1990 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Overfeeding: cardiovascular and metabolic response during continuous formula infusion in adult humans

K Casper, DE Matthews and SB Heymsfield
Department of Biochemistry, Emory University School of Medicine, Atlanta.

The cardiovascular and metabolic response to continuous nasoenteric formula infusion was monitored in eight healthy men during three consecutive 1-wk balance periods: maintenance-stabilization, overfeeding at twice the maintenance infusion rate, and postoverfeeding return to maintenance infusion. Elemental balance, thermogenic, and stable-isotope studies carried out throughout protocol identified 1) two distinct phases during overfeeding (early, days 1-4, and late, days 4-7); 2) changes in extracellular fluid (sodium balance) as the major determinant of overfeeding weight gain; 3) individual differences in percentage of excess fuels retained during overfeeding (76-87%), derived from variation in both digestive and thermogenic processes; and 4) a sustained physiologic response during the postoverfeeding period. These initial findings suggest that individuals differ in response to overfeeding and that specific aspects of this variation are amenable to future study. In addition, the timing of observed fluid, metabolic, and cardiovascular changes during overfeeding suggests specific strategies aimed at preventing refeeding circulatory complications.




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Copyright © 1990 by The American Society for Nutrition