American Journal of Clinical Nutrition, Vol 52, 661-666, Copyright © 1990 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Comparative effects of three cereal brans on plasma lipids, blood pressure, and glucose metabolism in mildly hypercholesterolemic men

M Kestin, R Moss, PM Clifton and PJ Nestel
CSIRO Division of Human Nutrition, Adelaide, Australia.

Dietary fiber lowers atherogenic serum lipids and blood pressure and improves glucose metabolism. We compared in 24 mildly hypercholesterolemic men the effects of adding 11.8 g dietary fiber/d from each of three cereal brans (wheat, rice, and oat) to a low-fiber diet for 4 wk each. A double-blind, crossover design incorporated brans into bread and muffins. Plasma total- and low-density-lipoprotein- cholesterol concentrations were significantly lowered only by oat bran. Compared with wheat bran, the ratios of plasma high-density-lipoprotein cholesterol to total cholesterol and of apolipoprotein A-I to B were significantly increased with oat bran (both by 4.7%, P less than 0.05), and rice bran (2.3%, P less than 0.05, and 3.9%, P less than 0.05, respectively). Blood pressure, blood glucose, and serum insulin responses to a common test meal were unaltered. Oat and rice bran exert a small but potentially useful effect on plasma lipoprotein risk factors for cardiovascular disease.

This article has been cited by other articles:

				S.-S. Huang, S.-H. Sung, and C.-E. Chiang Chitosan Potentiation of Warfarin Effect Ann. Pharmacother., November 1, 2007; 41(11): 1912 - 1914. [Abstract] [Full Text] [PDF]

				L. Wang, J M. Gaziano, S. Liu, J. E Manson, J. E Buring, and H. D Sesso Whole- and refined-grain intakes and the risk of hypertension in women Am. J. Clinical Nutrition, August 1, 2007; 86(2): 472 - 479. [Abstract] [Full Text] [PDF]

				A. E. Griel, E. H. Ruder, and P. M. Kris-Etherton The Changing Roles of Dietary Carbohydrates: From Simple to Complex Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1958 - 1965. [Abstract] [Full Text] [PDF]

				I. A Castro, L. P Barroso, and P. Sinnecker Functional foods for coronary heart disease risk reduction: a meta-analysis using a multivariate approach Am. J. Clinical Nutrition, July 1, 2005; 82(1): 32 - 40. [Abstract] [Full Text] [PDF]

				K. M. Behall, D. J. Scholfield, and J. Hallfrisch Comparison of Hormone and Glucose Responses of Overweight Women to Barley and Oats J. Am. Coll. Nutr., June 1, 2005; 24(3): 182 - 188. [Abstract] [Full Text] [PDF]

				M. M Most, R. Tulley, S. Morales, and M. Lefevre Rice bran oil, not fiber, lowers cholesterol in humans Am. J. Clinical Nutrition, January 1, 2005; 81(1): 64 - 68. [Abstract] [Full Text] [PDF]

				K. M Behall, D. J Scholfield, and J. Hallfrisch Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1185 - 1193. [Abstract] [Full Text] [PDF]

				T. A. Wilson, R. J. Nicolosi, B. Delaney, K. Chadwell, V. Moolchandani, T. Kotyla, S. Ponduru, G.-H. Zheng, R. Hess, N. Knutson, et al. Reduced and High Molecular Weight Barley {beta}-Glucans Decrease Plasma Total and Non-HDL-Cholesterol in Hypercholesterolemic Syrian Golden Hamsters J. Nutr., October 1, 2004; 134(10): 2617 - 2622. [Abstract] [Full Text] [PDF]

				K. M. Behall, D. J. Scholfield, and J. Hallfrisch Lipids Significantly Reduced by Diets Containing Barley in Moderately Hypercholesterolemic Men J. Am. Coll. Nutr., February 1, 2004; 23(1): 55 - 62. [Abstract] [Full Text] [PDF]

				G. F Keogh, G. J. Cooper, T. B Mulvey, B. H McArdle, G. D Coles, J. A Monro, and S. D Poppitt Randomized controlled crossover study of the effect of a highly {beta}-glucan-enriched barley on cardiovascular disease risk factors in mildly hypercholesterolemic men Am. J. Clinical Nutrition, October 1, 2003; 78(4): 711 - 718. [Abstract] [Full Text] [PDF]

				D. A. Kerckhoffs, G. Hornstra, and R. P Mensink Cholesterol-lowering effect of {beta}-glucan from oat bran in mildly hypercholesterolemic subjects may decrease when {beta}-glucan is incorporated into bread and cookies Am. J. Clinical Nutrition, August 1, 2003; 78(2): 221 - 227. [Abstract] [Full Text] [PDF]

				D. Geleva, W. Thomas, M. C. Gannon, and J. M. Keenan A Solubilized Cellulose Fiber Decreases Peak Postprandial Cholecystokinin Concentrations after a Liquid Mixed Meal in Hypercholesterolemic Men and Women J. Nutr., July 1, 2003; 133(7): 2194 - 2203. [Abstract] [Full Text] [PDF]

				B. Delaney, R. J. Nicolosi, T. A. Wilson, T. Carlson, S. Frazer, G.-H. Zheng, R. Hess, K. Ostergren, J. Haworth, and N. Knutson {beta}-Glucan Fractions from Barley and Oats Are Similarly Antiatherogenic in Hypercholesterolemic Syrian Golden Hamsters J. Nutr., February 1, 2003; 133(2): 468 - 475. [Abstract] [Full Text] [PDF]

				B. M Davy, K. P Davy, R. C Ho, S. D Beske, L. R Davrath, and C. L Melby High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men Am. J. Clinical Nutrition, August 1, 2002; 76(2): 351 - 358. [Abstract] [Full Text] [PDF]

				B. M. Davy, C. L. Melby, S. D. Beske, R. C. Ho, L. R. Davrath, and K. P. Davy Oat Consumption Does Not Affect Resting Casual and Ambulatory 24-h Arterial Blood Pressure in Men with High-Normal Blood Pressure to Stage I Hypertension J. Nutr., March 1, 2002; 132(3): 394 - 398. [Abstract] [Full Text] [PDF]

				E. Saltzman, S. K. Das, A. H. Lichtenstein, G. E. Dallal, A. Corrales, E. J. Schaefer, A. S. Greenberg, and S. B. Roberts An Oat-Containing Hypocaloric Diet Reduces Systolic Blood Pressure and Improves Lipid Profile beyond Effects of Weight Loss in Men and Women J. Nutr., May 1, 2001; 131(5): 1465 - 1470. [Abstract] [Full Text]

				J. A Lovegrove, A. Clohessy, H. Milon, and C. M Williams Modest doses of {beta}-glucan do not reduce concentrations of potentially atherogenic lipoproteins Am. J. Clinical Nutrition, July 1, 2000; 72(1): 49 - 55. [Abstract] [Full Text] [PDF]

				J. Hallfrisch and K. M. Behall Mechanisms of the Effects of Grains on Insulin and Glucose Responses J. Am. Coll. Nutr., June 1, 2000; 19(90003): 320S - 325. [Abstract] [Full Text] [PDF]

				L. Brown, B. Rosner, W. W Willett, and F. M Sacks Cholesterol-lowering effects of dietary fiber: a meta-analysis Am. J. Clinical Nutrition, January 1, 1999; 69(1): 30 - 42. [Abstract] [Full Text] [PDF]

				A. L. Gerhardt and N. B. Gallo Full-Fat Rice Bran and Oat Bran Similarly Reduce Hypercholesterolemia in Humans J. Nutr., May 1, 1998; 128(5): 865 - 869. [Abstract] [Full Text]

				A. Ascherio, C. Hennekens, W. C. Willett, F. Sacks, B. Rosner, J. Manson, J. Witteman, and M. J. Stampfer Prospective Study of Nutritional Factors, Blood Pressure, and Hypertension Among US Women Hypertension, May 1, 1996; 27(5): 1065 - 1072. [Abstract] [Full Text]