AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vanderpas, J. B.
Right arrow Articles by Diplock, A. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vanderpas, J. B.
Right arrow Articles by Diplock, A. T.
Agricola
Right arrow Articles by Vanderpas, J. B.
Right arrow Articles by Diplock, A. T.

American Journal of Clinical Nutrition, Vol 52, 1087-1093, Copyright © 1990 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Iodine and selenium deficiency associated with cretinism in northern Zaire

JB Vanderpas, B Contempre, NL Duale, W Goossens, N Bebe, R Thorpe, K Ntambue, J Dumont, CH Thilly and AT Diplock
Public Health School, Free University of Brussels, Belgium.

Selenium status was determined in an endemic-goiter area and in a control area of Zaire. Compared with the reference values of a noniodine-deficient area, serum selenium in subjects living in the core of the northern Zaire endemic-goiter belt (Karawa villages) was seven times lower in 52 school-children and similarly low in 23 cretins; erythrocyte glutathione peroxidase (RBC-GPX) was five times lower in schoolchildren and still two times lower in cretins (P = 0.004). In a less severely iodine-deficient city of the same endemia (Businga), selenium status was moderately altered. RBC-GPX activity was linearly associated with serum selenium concentration up to a value of 1140 nmol/L and leveled off at approximately 15 U/g Hb at greater selenium concentration. At Karawa villages, selenium supplementation normalized both the serum selenium and the RBC-GPX. This combined iodine and selenium deficiency could be associated with the elevated frequency of endemic myxedematous cretinism in Central Africa.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
J. Kohrle, F. Jakob, B. Contempre, and J. E. Dumont
Selenium, the Thyroid, and the Endocrine System
Endocr. Rev., December 1, 2005; 26(7): 944 - 984.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Contempre, G. M. de Escobar, J.-F. Denef, J. E. Dumont, and M.-C. Many
Thiocyanate Induces Cell Necrosis and Fibrosis in Selenium- and Iodine-Deficient Rat Thyroids: A Potential Experimental Model for Myxedematous Endemic Cretinism in Central Africa
Endocrinology, February 1, 2004; 145(2): 994 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. Moreno-Reyes, F. Mathieu, M. Boelaert, F. Begaux, C. Suetens, M. T Rivera, J. Neve, N. Perlmutter, and J. Vanderpas
Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy
Am. J. Clinical Nutrition, July 1, 2003; 78(1): 137 - 144.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. C. Bianco, D. Salvatore, B. Gereben, M. J. Berry, and P. R. Larsen
Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases
Endocr. Rev., February 1, 2002; 23(1): 38 - 89.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
F DELANGE
Iodine deficiency as a cause of brain damage
Postgrad. Med. J., April 1, 2001; 77(906): 217 - 220.
[Abstract] [Full Text]

Home page
 Am. J. Clin. Nutr.Home page
M. Zimmermann, P. Adou, T. Torresani, C. Zeder, and R. Hurrell
Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Cote d'Ivoire1
Am. J. Clinical Nutrition, January 1, 2000; 71(1): 88 - 93.
[Abstract] [Full Text] [PDF]

Home page
 Asia Pac J Public HealthHome page
C. Yamada, D. Oyunchimeg, P. Enkhtuya, A. Erdenbat, A. Buttumur, and T. Umenai
Current Status of Iodine Deficiency in Mongolia in 1998-1999
Asia Pac J Public Health, January 1, 2000; 12(2): 79 - 84.
[Abstract] [PDF]

Home page
 J. Nutr.Home page
M. Ruz, J. Codoceo, J. Galgani, L. Munoz, N. Gras, S. Muzzo, L. Leiva, and C. Bosco
Single and Multiple Selenium-Zinc-Iodine Deficiencies Affect Rat Thyroid Metabolism and Ultrastructure
J. Nutr., January 1, 1999; 129(1): 174 - 180.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. Moreno-Reyes, C. Suetens, F. Mathieu, F. Begaux, D. Zhu, M. T. Rivera, M. Boelaert, J. Neve, N. Perlmutter, and J. Vanderpas
Kashin-Beck Osteoarthropathy in Rural Tibet in Relation to Selenium and Iodine Status
N. Engl. J. Med., October 15, 1998; 339(16): 1112 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. D. Utiger
Kashin-Beck Disease -- Expanding the Spectrum of Iodine-Deficiency Disorders
N. Engl. J. Med., October 15, 1998; 339(16): 1156 - 1158.
[Full Text]

Home page
 EndocrinologyHome page
R. Ekholm and U. Bjorkman
Glutathione Peroxidase Degrades Intracellular Hydrogen Peroxide and Thereby Inhibits Intracellular Protein Iodination in Thyroid Epithelium
Endocrinology, July 1, 1997; 138(7): 2871 - 2878.
[Abstract] [Full Text] [PDF]

Home page
 Geological Society, London, Special PublicationsHome page
R. Fuge
Geochemistry of iodine in relation to iodine deficiency diseases
Geological Society, London, Special Publications, January 1, 1996; 113(1): 201 - 211.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by The American Society for Nutrition